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    2-(cyclic amino)-pyrimidone derivatives
    7.
    发明授权
    2-(cyclic amino)-pyrimidone derivatives 失效
    2-（环状氨基） - 嘧啶酮衍生物

    公开(公告)号：US08569294B2

    公开(公告)日：2013-10-29

    申请号：US12282396

    申请日：2007-03-14

    申请人： Kenji Fukunaga ,  Toshiyuki Kohara ,  Kazutoshi Watanabe ,  Yoshihiro Usui ,  Fumiaki Uehara ,  Satoshi Yokoshima ,  Daiki Sakai ,  Shin-ichi Kusaka ,  Kazuki Nakayama

    发明人： Kenji Fukunaga ,  Toshiyuki Kohara ,  Kazutoshi Watanabe ,  Yoshihiro Usui ,  Fumiaki Uehara ,  Satoshi Yokoshima ,  Daiki Sakai ,  Shin-ichi Kusaka ,  Kazuki Nakayama

    IPC分类号： A61K31/535

    CPC分类号： C07D413/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D453/06 ,  C07D493/04

    摘要： A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R2 represents a hydrogen or the like; R3 represents methyl group or the like; R20 represents a halogen atom or the like; q represents an integer of 0 to 3; Z represent nitrogen atom, CH, or the like; R4 represents hydrogen or the like; R5 represents hydrogen or the like; R6 represents a substituted alkyloxy and the like; p represents an integer of 0 to 3; X represents bond, CH2, oxygen atom, NH, or the like; any one or more of R5 and R6, R5 and R4, R6 and R4, X and R5, X and R4, X and R6, and R6 and R6 may combine to each other to form a ring, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

    摘要翻译： 由式（I）表示的化合物或其光学活性异构体或其药学上可接受的盐：其中R2表示氢等; R3表示甲基等; R 20表示卤素原子等; q表示0〜3的整数， Z表示氮原子，CH等; R4表示氢等; R5表示氢等; R6表示取代的烷氧基等; p表示0〜3的整数， X表示键，CH2，氧原子，NH等; R 5和R 6，R 5和R 4，R 6和R 4，X和R 5，X和R 4，X和R 6以及R 6和R 6中的任何一个或多个可以彼此结合形成环，其用于预防和/ 或治疗由tau蛋白激酶1多动症如神经变性疾病（例如阿尔茨海默病）引起的疾病。

    3-substituted-4-pyrimidone derivatives
    9.
    发明授权
    3-substituted-4-pyrimidone derivatives 失效
    3-取代-4-嘧啶酮衍生物

    公开(公告)号：US07683069B2

    公开(公告)日：2010-03-23

    申请号：US10538766

    申请日：2003-12-12

    申请人： Yoshihiro Usui ,  Masahiro Okuyama ,  Tokushi Hanano

    发明人： Yoshihiro Usui ,  Masahiro Okuyama ,  Tokushi Hanano

    IPC分类号： C07D401/14 ,  A61K31/505

    CPC分类号： C07D401/14 ,  C07D409/14 ,  C07D413/14

    摘要： A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof useful as a tau protein kinase 1 inhibitor: wherein X represents CH or nitrogen atom; R1 represents a C?1#191-C?12#191 alkyl group which may be substituted; R2 represents a C?1#191-C?8#191 alkyl group which may be substituted, a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom, and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.

    摘要翻译： 用作tau蛋白激酶1抑制剂的由式（I）表示的嘧啶酮衍生物或其盐或其溶剂合物或其水合物：其中X表示CH或氮原子; R1表示可被取代的C 1〜191-C 12〜191烷基; R2表示可被取代的C 1〜191-C 18〜191烷基，可被取代的苯环，可被取代的萘环，可被取代的茚满环，可以被取代的四氢萘环， 或具有1〜4个选自氧原子，硫原子和氮原子的杂原子的任意取代的杂环，并且总共具有5〜10个构成环的原子。

    3-Substituted-4-pyrimidone derivatives
    10.
    发明申请
    3-Substituted-4-pyrimidone derivatives 失效
    3-取代的-4-嘧啶酮衍生物

    公开(公告)号：US20070142409A1

    公开(公告)日：2007-06-21

    申请号：US10538766

    申请日：2003-12-12

    申请人： Yoshihiro Usui ,  Masahiro Okuyama ,  Tokushi Hanano

    发明人： Yoshihiro Usui ,  Masahiro Okuyama ,  Tokushi Hanano

    IPC分类号： A61K31/513 ,  C07D403/14

    CPC分类号： C07D401/14 ,  C07D409/14 ,  C07D413/14

    摘要： A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof useful as a tau protein kinase 1 inhibitor:wherein X represents CH or nitrogen atom; R1 represents a C?1#191-C?12#191 alkyl group which may be substituted; R2 represents a C?1#191-C?8#191 alkyl group which may be substituted, a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom, and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.

    摘要翻译： 用作tau蛋白激酶1抑制剂的由式（I）表示的嘧啶酮衍生物或其盐或其溶剂合物或其水合物：其中X表示CH或氮原子; R 1表示可被取代的C 1〜1 191〜C 12〜191烷基; R 2表示可以被取代的C 1〜191-C 18〜191烷基，可被取代的苯环，可被取代的萘环，可以被取代的萘环 可被取代的四氢萘环，或具有1-4个选自氧原子，硫原子和氮原子的杂原子的任意取代的杂环，并且总共具有5至10个环构成原子 。