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公开(公告)号:US20120034364A1
公开(公告)日:2012-02-09
申请号:US13249523
申请日:2011-09-30
申请人: FUMIE FUTAKI , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
发明人: FUMIE FUTAKI , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
摘要: The inventors of this invention have conducted the search for a variety of compounds which may possess a desired CaSR agonist activity to thus find out a substance capable of imparting a kokumi, which shows a more excellent kokumi-imparting effect, in particular, a kokumi-imparting effect of the initial taste-imparting type one, which is excellent in the stability and which can easily be produced at a low cost and the present invention thus provide a kokumi-imparting agent consisting of such a substance as well as a complex kokumi-imparting agent comprising the substance and other substances possessing the CaSR agonist activities in combination. More particularly, the present invention herein provides a kokumi-imparting agent consisting of γ-Glu-Abu (L-γ-glutamyl-L-2-amino-butyric acid) and a complex kokumi-imparting agent comprising the foregoing substance and another substance having a CaSR agonist activity, in combination.
摘要翻译: 本发明的发明人已经进行了可能具有所需CaSR激动剂活性的各种化合物的寻找,从而找出能够赋予kokumi的物质,这表现出更优异的赋粉效果,特别是kokumi- 赋予了稳定性优异且易于以低成本制造的初始味觉赋予型赋予效果,因此本发明提供了由这种物质组成的赋粉剂以及复合的kokumi- 包含该物质和具有CaSR激动剂活性的其它物质组合的赋形剂。 更具体地说,本发明提供由γ-Glu-Abu(L-γ-谷氨酰基-L-2-氨基 - 丁酸)和包含上述物质的复合kokumi赋予剂和另一种物质 具有CaSR激动剂活性。
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公开(公告)号:US09844226B2
公开(公告)日:2017-12-19
申请号:US13249523
申请日:2011-09-30
申请人: Fumie Futaki , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
发明人: Fumie Futaki , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
摘要: A substance is described which is capable of imparting a kokumi, which shows a more excellent kokumi-imparting effect, in particular, the initial taste-imparting type of kokumi-imparting effect, which is excellent in the stability and which can easily be produced at a low cost. Additionally, a kokumi-imparting composition which includes a substance as well as a kokumi-imparting agent including the substance and other substances possessing the CaSR agonist activities in combination. More particularly, the present invention herein provides a kokumi-imparting composition consisting of γ-Glu-Abu (L-γ-glutamyl-L-2-amino-butyric acid) and a complex kokumi-imparting agent which includes the foregoing substance and another substance having a CaSR agonist activity, in combination.
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公开(公告)号:US08568814B2
公开(公告)日:2013-10-29
申请号:US13533469
申请日:2012-06-26
申请人: Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
发明人: Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
IPC分类号: A23L1/226
CPC分类号: A23C9/156 , A23L27/204 , C07D281/06 , C07K5/0215
摘要: The present invention provides a variety of compounds having a CaSR agonist activity which possesses a superior kokumi-imparting function, and more particularly provides a kokumi-imparting composition, which contains the foregoing compound, and/or another substance having a CaSR agonist activity, in combination. The present invention also provides a kokumi-imparting composition which includes a lanthionine derivative and/or another substance having a CaSR agonist activity.
摘要翻译: 本发明提供了各种具有CaSR激动剂活性的化合物,其具有优异的赋粉功能,更具体地,提供含有上述化合物和/或另一种具有CaSR激动剂活性的物质,赋予赋粉组合物, 组合。 本发明还提供了一种赋形剂组合物,其包含具有CaSR激动剂活性的叶酸衍生物和/或其它物质。
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公开(公告)号:US20120282386A1
公开(公告)日:2012-11-08
申请号:US13533469
申请日:2012-06-26
申请人: Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
发明人: Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
IPC分类号: C07D281/06 , A23L1/226
CPC分类号: A23C9/156 , A23L27/204 , C07D281/06 , C07K5/0215
摘要: The present invention provides a variety of compounds having a CaSR agonist activity which possesses a superior kokumi-imparting function, and more particularly provides a kokumi-imparting composition, which contains the foregoing compound, and/or another substance having a CaSR agonist activity, in combination. The present invention also provides a kokumi-imparting composition which includes a lanthionine derivative and/or another substance having a CaSR agonist activity.
摘要翻译: 本发明提供了各种具有CaSR激动剂活性的化合物,其具有优异的赋粉功能,更具体地,提供含有上述化合物和/或另一种具有CaSR激动剂活性的物质,赋予赋粉组合物, 组合。 本发明还提供了一种赋形剂组合物,其包含具有CaSR激动剂活性的叶酸衍生物和/或其它物质。
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公开(公告)号:US20120277168A1
公开(公告)日:2012-11-01
申请号:US13529482
申请日:2012-06-21
申请人: Takashi Miyaki , Naohiro Miyamura , Megumi Kaneko , Yusuke Amino , Reiko Yasuda , Yuzuru Eto , Takaho Tajima
发明人: Takashi Miyaki , Naohiro Miyamura , Megumi Kaneko , Yusuke Amino , Reiko Yasuda , Yuzuru Eto , Takaho Tajima
IPC分类号: A61K38/05
CPC分类号: C07K5/0215 , A23L27/22 , A23L27/63 , A23L27/88
摘要: A substance capable of imparting a kokumi having CaSR agonist activity is described. This substance is able to impart kokumi in a superior manner, in particular, at the initial taste, and is also highly stable and can easily be produced at a low cost. The present invention thus provides a kokumi-imparting composition which includes such a substance as well as a complex kokumi-imparting composition which includes the substance and other substances possessing the CaSR agonist activities in combination. More particularly, the present invention herein provides a kokumi-imparting composition including γ-Glu-Nva (L-γ-glutamyl-L-norvaline), and a complex kokumi-imparting composition including the foregoing substance and another substance having a CaSR agonist activity, in combination.
摘要翻译: 描述能够赋予具有CaSR激动剂活性的kokumi的物质。 该物质能够以优异的方式,特别是以初始味道赋予kokumi,并且还高度稳定,并且可以以低成本容易地生产。 因此,本发明提供了包含这种物质以及组合的包含该物质和其它具有CaSR激动剂活性的其它物质的复合的赋粉组合物的赋粉赋形剂组合物。 更具体地说,本发明提供了包含γ-Glu-Nva(L-γ-谷氨酰基-L-降盏花素)的赋形组合物和包含上述物质的赋形复合组合物和另一种具有CaSR激动剂活性物质 , 结合。
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公开(公告)号:US08541379B2
公开(公告)日:2013-09-24
申请号:US13529482
申请日:2012-06-21
申请人: Takashi Miyaki , Naohiro Miyamura , Megumi Kaneko , Yusuke Amino , Reiko Yasuda , Yuzuru Eto , Takaho Tajima
发明人: Takashi Miyaki , Naohiro Miyamura , Megumi Kaneko , Yusuke Amino , Reiko Yasuda , Yuzuru Eto , Takaho Tajima
IPC分类号: A61K38/05 , A61K38/00 , A23B7/10 , A23B4/023 , A23F3/00 , A23K1/00 , A23L1/22 , A23L2/56 , A23L1/236 , A23L1/40 , A23L1/238 , A23L2/00 , A23L2/38 , A23L1/212 , A23L1/223 , A23L1/221 , A23L3/015 , A23D9/013 , A21D2/16 , A23J1/00 , A23P1/00 , A22C13/00
CPC分类号: C07K5/0215 , A23L27/22 , A23L27/63 , A23L27/88
摘要: A substance capable of imparting a kokumi having CaSR agonist activity is described. This substance is able to impart kokumi in a superior manner, in particular, at the initial taste, and is also highly stable and can easily be produced at a low cost. The present invention thus provides a kokumi-imparting composition which includes such a substance as well as a complex kokumi-imparting composition which includes the substance and other substances possessing the CaSR agonist activities in combination. More particularly, the present invention herein provides a kokumi-imparting composition including γ-Glu-Nva (L-γ-glutamyl-L-norvaline), and a complex kokumi-imparting composition including the foregoing substance and another substance having a CaSR agonist activity, in combination.
摘要翻译: 描述能够赋予具有CaSR激动剂活性的kokumi的物质。 该物质能够以优异的方式,特别是以初始味道赋予kokumi,并且还高度稳定,并且可以以低成本容易地生产。 因此,本发明提供了包含这种物质以及组合的包含该物质和其它具有CaSR激动剂活性的其它物质的复合的赋粉组合物的赋粉赋形剂组合物。 更具体地说,本发明提供了包含γ-Glu-Nva(L-γ-谷氨酰基-L-降盏花素)的赋形剂组合物和包含上述物质的复合体系组合物和另一种具有CaSR激动剂活性的物质 , 结合。
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公开(公告)号:US08796485B2
公开(公告)日:2014-08-05
申请号:US13079273
申请日:2011-04-04
申请人: Masayuki Sugiki , Toru Okamatsu , Sayaka Asari , Yayoi Kawato , Toshihiro Hatanaka , Tetsuo Yano , Yukie Seki , Naohiro Miyamura , Hiroaki Nagasaki , Yuzuru Eto , Reiko Yasuda
发明人: Masayuki Sugiki , Toru Okamatsu , Sayaka Asari , Yayoi Kawato , Toshihiro Hatanaka , Tetsuo Yano , Yukie Seki , Naohiro Miyamura , Hiroaki Nagasaki , Yuzuru Eto , Reiko Yasuda
IPC分类号: A23L1/228 , C07C237/04 , C07C309/51 , C07F9/40 , C07F9/38 , A23L1/305
CPC分类号: C07C237/04 , A23L27/204 , A23L27/22 , A23L33/175 , C07C309/51 , C07F9/3834 , C07F9/4018 , C07F9/4021
摘要: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
摘要翻译: 通过搜索具有CaSR激动活性的各种化合物,本发明提供了各自包含该化合物的CaSR激动剂,药物组合物,用于腹泻和诱导剂的预防或治疗剂。 更具体地,本发明提供了CaSR激动剂,药物组合物,用于腹泻和赋予Kokumi的预防或治疗剂,其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。
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公开(公告)号:US20110251418A1
公开(公告)日:2011-10-13
申请号:US13079273
申请日:2011-04-04
申请人: Masayuki Sugiki , Toru Okamatsu , Sayaka Asari , Yayoi Kawato , Toshihiro Hatanaka , Tetsuo Yano , Yukie Seki , Naohiro Miyamura , Hiroaki Nagasaki , Yuzuru Eto , Reiko Yasuda
发明人: Masayuki Sugiki , Toru Okamatsu , Sayaka Asari , Yayoi Kawato , Toshihiro Hatanaka , Tetsuo Yano , Yukie Seki , Naohiro Miyamura , Hiroaki Nagasaki , Yuzuru Eto , Reiko Yasuda
IPC分类号: C07F9/40 , C07F9/38 , C07C237/20 , C07C309/61
CPC分类号: C07C237/04 , A23L27/204 , A23L27/22 , A23L33/175 , C07C309/51 , C07F9/3834 , C07F9/4018 , C07F9/4021
摘要: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
摘要翻译: 通过搜索具有CaSR激动活性的各种化合物,本发明提供了各自包含该化合物的CaSR激动剂,药物组合物,用于腹泻和赋形剂的预防或治疗剂。 更具体地,本发明提供了CaSR激动剂,药物组合物,用于腹泻和赋予Kokumi的预防或治疗剂,其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。
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公开(公告)号:US08173605B2
公开(公告)日:2012-05-08
申请号:US12117027
申请日:2008-05-08
申请人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
IPC分类号: C07K5/06
CPC分类号: G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译: 本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法,含有通过筛选方法得到的赋予口味的物质的组合物,赋予口味的食品或饮料的制造方法,以及 送给kokumi的食物或饮料。
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公开(公告)号:US20110097805A1
公开(公告)日:2011-04-28
申请号:US12962051
申请日:2010-12-07
申请人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
IPC分类号: G01N33/02
CPC分类号: G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译: 本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法,含有通过筛选方法得到的赋予口味的物质的组合物,赋予口味的食品或饮料的制造方法,以及 送给kokumi的食物或饮料。
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