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公开(公告)号：US20210113668A1
公开(公告)日：2021-04-22
申请号：US16969092
申请日：2019-02-12
发明人： Seong-Hyun HO , Su Jin PARK
IPC分类号： A61K38/30 , A61K9/50 , A61K31/02 , A61K33/16 , A61K31/035 , A61K31/025 , A61P25/02 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/06 , A61K47/18 , A61K38/18
摘要： The present disclosure relates to a composition for increasing the expression of a growth factor gene, which contains core-shell structured microparticles as an active ingredient. When administered in vivo along with a growth factor gene, the composition for increasing the expression of a growth factor gene of the present disclosure can increase the expression of the co-administered gene by at least 30%. Especially, when administered along with at least one gene selected from a human hepatocyte growth factor (HGF) gene, an isoform gene of the human hepatocyte growth factor and a variant gene thereof, or at least one gene selected from a human insulin-like growth factor 1 (IGF1) gene, an isoform gene of the human insulin-like growth factor 1 and a variant gene thereof, which are appropriate for the present disclosure, the composition can increase the expression of the gene by at least 30%. When administered along with a gene therapeutic agent, the composition can achieve a therapeutic effect even with a very small amount of a gene, and thus is useful.
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公开(公告)号：US20230390211A1
公开(公告)日：2023-12-07
申请号：US18062252
申请日：2022-12-06
发明人： Seong-Hyun HO , Su Jin PARK
IPC分类号： A61K9/50 , A61P7/04 , A61K38/37 , A61P25/02 , A61K31/02 , A61K31/025 , A61K31/035 , A61K33/16 , A61K38/18 , A61K38/30 , A61K47/06 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/28
CPC分类号： A61K9/5015 , A61P7/04 , A61K38/37 , A61P25/02 , A61K31/02 , A61K31/025 , A61K31/035 , A61K33/16 , A61K38/1833 , A61K38/30 , A61K47/06 , A61K47/186 , A61K47/24 , A61K47/26 , A61K47/28 , A61K48/00
摘要： The present disclosure relates to a composition for increasing the expression of a blood coagulation factor gene, which contains core-shell structured microparticles as an active ingredient. When administered in vivo along with blood coagulation factor VIII gene or a variant gene thereof, the composition for increasing the expression of a blood coagulation factor gene of the present disclosure can increase the expression of the gene by at least 30%. When administered along with a gene therapeutic agent, the composition can achieve a therapeutic effect even with a very small amount of a gene, and thus is useful.
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公开(公告)号：US20210163575A1
公开(公告)日：2021-06-03
申请号：US16770678
申请日：2018-12-05
发明人： Seong-Hyun HO , Su Jin PARK
IPC分类号： C07K14/755 , A61K48/00 , C12N15/85
摘要： The present disclosure relates to an expression vector that carries a polynucleotide coding for a coagulation factor VIII mutant and has increased protein expression and a pharmaceutical composition containing the expression vector for preventing or treating hemorrhagic disease or hemorrhage.
The factor VIII mutant of the present disclosure is derived by deleting a part of the B-domain (residues 784-1667) and a part of the a3 region (residues 1668-1671) in factor VIII and, as a result, an expression vector carrying a polynucleotide coding for the factor VIII mutant has remarkably increased protein expression.-
4.发明申请公开(公告)号：US20220193163A1
公开(公告)日：2022-06-23
申请号：US17605483
申请日：2020-04-24
发明人： Su Jin PARK , Seong-Hyun HO
IPC分类号： A61K36/18 , A23L33/105 , A61P17/16
摘要： The present disclosure relates to a composition for alleviating ultraviolet ray-induced skin damage or moisturizing skin, more particularly, to a composition containing an Actinidia polygama extract as an active ingredient. The composition can alleviate the reduction of skin moisture caused by ultraviolet ray-induced skin barrier damage and the resultant skin dryness, reduced skin elasticity and increased skin roughness and, as such, can be utilized as a food composition for alleviating ultraviolet ray-induced skin damage or moisturizing skin and, furthermore, as a health functional food or pharmaceutical composition, an animal feed composition, a pharmaceutical composition for animals or a cosmetic composition.
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公开(公告)号：US20230212603A1
公开(公告)日：2023-07-06
申请号：US17495233
申请日：2021-10-06
发明人： Seong Hyun HO , Su Jin PARK
IPC分类号： C12N15/85 , C12N7/00 , C07K14/005 , C07K14/475 , A61K48/00
CPC分类号： C12N15/85 , A61K48/0066 , C07K14/005 , C07K14/4753 , C12N7/00 , C12N2710/16143 , C12N2800/107 , C12N2830/34
摘要： The present disclosure relates to development of a eukaryotic cell expression vector satisfying optimized conditions for gene therapies and DNA vaccines. As a result of replacing the full HCMV regulatory and transcribed region including the immediate early (IE) gene intron A of the HCMV Towne strain and the same region of various HCMV strains at the pVAX1 promoter region and comparing the difference in gene expression efficiency for the different HCMV strains, the eukaryotic cell expression vector of the present disclosure could increase the expression of various genes by about 50-150% as compared to the HCMV Towne strain. Through this, pHP3 was developed as a vector exhibiting high expression in eukaryotic cells, and it can be usefully used for gene therapies or DNA vaccines.
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公开(公告)号：US20210113480A1
公开(公告)日：2021-04-22
申请号：US16969040
申请日：2019-02-12
发明人： Seong-Hyun HO , Su Jin PARK
摘要： The present disclosure relates to a composition for increasing the expression of a blood coagulation factor gene, which contains core-shell structured microparticles as an active ingredient. When administered in vivo along with blood coagulation factor VIII gene or a variant gene thereof, the composition for increasing the expression of a blood coagulation factor gene of the present disclosure can increase the expression of the gene by at least 30%. When administered along with a gene therapeutic agent, the composition can achieve a therapeutic effect even with a very small amount of a gene, and thus is useful.
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