公开(公告)号：US20050147967A1

公开(公告)日：2005-07-07

申请号：US10257763

申请日：2001-04-17

申请人： Götz Bernhard ,  Brigitta Kammandel ,  Rohini Kuner ,  Sigrid Scheek ,  Holger Hiemisch

发明人： Götz Bernhard ,  Brigitta Kammandel ,  Rohini Kuner ,  Sigrid Scheek ,  Holger Hiemisch

IPC分类号： C12N1/21 ,  C12N15/12 ,  C12Q1/68 ,  C12Q1/6883 ,  G01N33/574 ,  C07H21/04 ,  A61K48/00 ,  C12P21/02 ,  A61K39/395 ,  C12N9/64

CPC分类号： C12Q1/6883 ,  A01K2217/075 ,  C12Q2600/158

摘要： The invention relates to novel specifically expressed proteins, and to nucleic acid sequences or recombinant nucleic acid constructs encoding said proteins. The invention further relates to host organisms or transgenic animals containing said nucleic acid sequences or recombinant nucleic acid constructs, and to monoclonal or polyclonal antibodies directed to the isolated proteins. The invention also relates to a method for finding substances having a specific binding affinity to the inventive proteins, and to a method for the qualitative or quantitative analysis of the inventive nucleic acid sequences or inventive proteins. The invention further relates to the use of the nucleic acid sequences and proteins.

摘要翻译： 本发明涉及新型特异表达的蛋白质，以及编码所述蛋白质的核酸序列或重组核酸构建体。 本发明还涉及含有所述核酸序列或重组核酸构建体的宿主生物体或转基因动物，以及针对分离的蛋白质的单克隆或多克隆抗体。 本发明还涉及一种用于发现对本发明蛋白质具有特异性结合亲和力的物质的方法，以及本发明的核酸序列或本发明蛋白质的定性或定量分析方法。 本发明还涉及核酸序列和蛋白质的用途。

公开(公告)号：US06699660B2

公开(公告)日：2004-03-02

申请号：US09244805

申请日：1999-02-05

申请人： Paul F. Worley ,  Anthony Lanahan ,  Bernhard Goetz ,  Holger Hiemisch ,  Rohini Kuner ,  Sigrid Scheek ,  Karoly Nikolich ,  Eugene Zhukovsky

发明人： Paul F. Worley ,  Anthony Lanahan ,  Bernhard Goetz ,  Holger Hiemisch ,  Rohini Kuner ,  Sigrid Scheek ,  Karoly Nikolich ,  Eugene Zhukovsky

IPC分类号： C12N1563

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.

摘要翻译： 本发明提供了与立即早期基因相关的方法和材料。 具体地，本发明提供了分离的立即早期基因核酸，含有分离的立即早期基因核酸的细胞，由立即早期基因核酸编码的基本上纯的多肽，以及对由立即早期基因核酸编码的多肽具有特异性结合亲和力的抗体。 此外，本发明提供富集立即早期基因cDNA的cDNA文库，源自此类cDNA文库的分离的核酸，以及用于治疗与神经元对刺激的即时早期基因反应性缺陷有关的病症的方法。