公开(公告)号：US20050003480A1

公开(公告)日：2005-01-06

申请号：US10820465

申请日：2004-03-31

Applicant: John Desjarlais ,  Eugene Zhukovsky

Inventor： John Desjarlais ,  Eugene Zhukovsky

IPC: A61K38/00 ,  C07K14/525 ,  C07K14/705 ,  A61K38/17 ,  C07H21/04

CPC classification number: C07K14/525 ,  A61K38/00 ,  C07K14/70575 ,  C07K2319/00

Abstract: The invention relates to novel proteins of APRIL variants that modulate the biological activity as compared to naturally occurring APRIL or BAFF and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or APRIL-related disorders.

Abstract translation: 本发明涉及与天然存在的APRIL或BAFF和编码这些蛋白质的核酸相比调节生物活性的APRIL变体的新蛋白质。 本发明还涉及新型蛋白质在治疗BAFF或APRIL相关疾病中的用途。

公开(公告)号：US20050130892A1

公开(公告)日：2005-06-16

申请号：US10944473

申请日：2004-09-16

Applicant: John Desjarlais ,  Adam Thomason ,  Eugene Zhukovsky ,  Seung Chu

Inventor： John Desjarlais ,  Adam Thomason ,  Eugene Zhukovsky ,  Seung Chu

IPC: A61K38/00 ,  C07K14/525 ,  C07K14/705 ,  A61K38/18 ,  C07K14/475

CPC classification number: C07K14/70575 ,  A61K38/00 ,  C07K14/525 ,  C07K2319/00 ,  C07K2319/43

Abstract: The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or APRIL-related disorders.

Abstract translation: 本发明涉及具有BAFF显性负性拮抗剂的新型蛋白质，受体拮抗剂活性和激动剂活性以及编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗BAFF或APRIL相关疾病中的用途。

公开(公告)号：US20050054053A1

公开(公告)日：2005-03-10

申请号：US10820467

申请日：2004-03-30

Applicant: Anna Aguinaldo ,  Amelia Beyna ,  Ho Cho ,  John Desjarlais ,  Shannon Marshall ,  Umesh Muchhal ,  Michael Villegas ,  Eugene Zhukovsky ,  Michael Quesenberry

Inventor： Anna Aguinaldo ,  Amelia Beyna ,  Ho Cho ,  John Desjarlais ,  Shannon Marshall ,  Umesh Muchhal ,  Michael Villegas ,  Eugene Zhukovsky ,  Michael Quesenberry

IPC: A61K38/00 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07H21/04 ,  C12P21/04

CPC classification number: C07K14/565 ,  A61K38/00 ,  C07K14/555 ,  C07K14/56

Abstract: The invention relates to interferon variants with improved properties and methods for their use.

Abstract translation: 本发明涉及具有改进的性质和用途的干扰素变体。

公开(公告)号：US06699660B2

公开(公告)日：2004-03-02

申请号：US09244805

申请日：1999-02-05

Applicant: Paul F. Worley ,  Anthony Lanahan ,  Bernhard Goetz ,  Holger Hiemisch ,  Rohini Kuner ,  Sigrid Scheek ,  Karoly Nikolich ,  Eugene Zhukovsky

Inventor： Paul F. Worley ,  Anthony Lanahan ,  Bernhard Goetz ,  Holger Hiemisch ,  Rohini Kuner ,  Sigrid Scheek ,  Karoly Nikolich ,  Eugene Zhukovsky

IPC: C12N1563

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.

Abstract translation: 本发明提供了与立即早期基因相关的方法和材料。 具体地，本发明提供了分离的立即早期基因核酸，含有分离的立即早期基因核酸的细胞，由立即早期基因核酸编码的基本上纯的多肽，以及对由立即早期基因核酸编码的多肽具有特异性结合亲和力的抗体。 此外，本发明提供富集立即早期基因cDNA的cDNA文库，源自此类cDNA文库的分离的核酸，以及用于治疗与神经元对刺激的即时早期基因反应性缺陷有关的病症的方法。

公开(公告)号：US20090271207A1

公开(公告)日：2009-10-29

申请号：US12150453

申请日：2008-04-29

Applicant: William P. Lanigan ,  Maciej Labowicz ,  David S. Schuman ,  Eugene Zhukovsky ,  John Wepfer ,  Gary A. Naese

Inventor： William P. Lanigan ,  Maciej Labowicz ,  David S. Schuman ,  Eugene Zhukovsky ,  John Wepfer ,  Gary A. Naese

IPC: G06Q99/00 ,  H04L9/32

CPC classification number: G07C9/00103 ,  G07C2209/08

Abstract: An enhanced delivery system (300) for field service providers is disclosed. In its simplest form, the delivery system (300), can comprise the steps of: granting (305) permission to a service provider to provide a designated service at an assigned location; traveling (310) to the assigned location to provide a service; remotely actuating (315) an access point to gain access to a restricted area; accessing (320) the restricted area through the access point; providing (325) a service in connection with the restricted area; and closing (330) the access point after accessing the restricted area. The system (300) facilitates and simplifies access to restricted areas, and contributes to routinizing the service process for enhanced efficiencies.

Abstract translation: 公开了一种用于现场服务提供商的增强型传送系统（300）。 在其最简单的形式中，传送系统（300）可以包括以下步骤：向服务提供商授予（305）许可以在分配的位置提供指定的服务; 旅行（310）到指定地点提供服务; 远程启动（315）接入点以访问受限制的区域; 通过接入点访问（320）限制区域; 提供（325）与限制区域相关的服务; 并在接入限制区域之后关闭（330）接入点。 系统（300）有助于和简化对限制区域的访问，并且有助于对服务过程进行例行化以提高效率。

公开(公告)号：US20050048626A1

公开(公告)日：2005-03-03

申请号：US10794751

申请日：2004-03-05

Applicant: John Desjarlais ,  Adam Thomason ,  Eugene Zhukovsky

Inventor： John Desjarlais ,  Adam Thomason ,  Eugene Zhukovsky

IPC: A61K38/00 ,  C07K14/525 ,  C07K14/705 ,  H04L29/06 ,  C07H21/04 ,  C12P21/02

CPC classification number: H04L65/1043 ,  A61K38/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2319/00 ,  H04L29/06027 ,  Y10S930/12

Abstract: The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or APRIL-related disorders.