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公开(公告)号:US20200269197A1
公开(公告)日:2020-08-27
申请号:US16851432
申请日:2020-04-17
申请人: GAMBRO LUNDIA AB
发明人: Adriana BOSCHETTI-DE-FIERRO , Manuel VOIGT , Bernd KRAUSE , Markus HORNUNG , Markus STORR , Heinrich BEHR , Werner BECK , Carina ZWEIGART , Reinhold BUCK , Philipp HERBST , Joachim LOERCHER , Arnd WOCHNER
摘要: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.
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公开(公告)号:US20200316533A1
公开(公告)日:2020-10-08
申请号:US16851439
申请日:2020-04-17
申请人: GAMBRO LUNDIA AB
发明人: Markus HORNUNG , Bernd KRAUSE , Markus STORR , Philipp HERBST , Arnd WOCHNER , Adriana BOSCHETTI-DE-FIERRO , Manuel VOIGT , Carina ZWEIGART , Joachim LOERCHER , Reinhold BUCK , Heinrich BEHR , Werner BECK
摘要: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
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公开(公告)号:US20200147287A1
公开(公告)日:2020-05-14
申请号:US16604454
申请日:2018-03-29
申请人: GAMBRO LUNDIA AB
发明人: Danilo DONATO , Sunny ELOOT , Carina ZWEIGART , Adriana BOSCHETTI-DE-FIERRO , Michael KOLB , Bernd KRAUSE , Markus STORR
摘要: The present disclosure concerns a hemodialyzer for the purification of blood and use thereof. The hemodialyzer comprises a bundle of hollow fiber membranes, wherein the hollow fiber membranes have an inner diameter (dB) within the range of 168-175 μm, a fiber wall thickness (δm) within the range of 25-26 μm, and an effective length (L) within the hemodialyzer within the range of 207-287 mm. The bundle of hollow fiber membranes has a packing density within the range of 57.5-60.0%, and a total membrane surface area (Atot) within the range of from 1.64 to 1.73 m2.
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公开(公告)号:US20220152563A1
公开(公告)日:2022-05-19
申请号:US17590097
申请日:2022-02-01
申请人: GAMBRO LUNDIA AB
发明人: Markus HORNUNG , Bernd KRAUSE , Markus STORR , Philipp HERBST , Arnd WOCHNER , Adriana BOSCHETTI-DE-FIERRO , Manuel VOIGT , Carina ZWEIGART , Joachim LOERCHER , Reinhold BUCK , Heinrich BEHR , Werner BECK
摘要: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
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公开(公告)号:US20170165615A1
公开(公告)日:2017-06-15
申请号:US15115951
申请日:2015-02-05
申请人: GAMBRO LUNDIA AB
发明人: Markus HORNUNG , Bernd KRAUSE , Markus STORR , Philipp HERBST , Arnd WOCHNER , Adriana BOSCHETTI-DE-FIERRO , Manuel VOIGT , Carina ZWEIGART , Joachim LOERCHER , Reinhold BUCK , Heinrich BEHR , Werner BECK
摘要: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
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公开(公告)号:US20170043299A1
公开(公告)日:2017-02-16
申请号:US15307106
申请日:2015-04-30
申请人: GAMBRO LUNDIA AB
发明人: Bernd KRAUSE , Ralf MENDA , Christof BECK , Joachim LOERCHER , Adriana BOSCHETTI-DE-FIERRO , Rainer BLICKLE
CPC分类号: B01D69/087 , A61M1/1686 , B01D67/009 , B01D67/0095 , B01D67/0097 , B01D71/68 , B01D2323/345 , B01D2323/42
摘要: The present invention relates to porous hollow fiber membranes suitable for hemodialysis, hemodiafiltration or hemofiltration of blood and processes for their production involving UV irradiation of the membrane.
摘要翻译: 本发明涉及适用于血液透析,血液透析过滤或血液滤过的多孔中空纤维膜及涉及紫外线照射的生产方法。
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公开(公告)号:US20220152562A1
公开(公告)日:2022-05-19
申请号:US17590085
申请日:2022-02-01
申请人: GAMBRO LUNDIA AB
发明人: Adriana BOSCHETTI-DE-FIERRO , Manuel VOIGT , Bernd KRAUSE , Markus HORNUNG , Markus STORR , Heinrich BEHR , Werner BECK , Carina ZWEIGART , Reinhold BUCK , Philipp HERBST , Joachim LOERCHER , Arnd WOCHNER
摘要: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.
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公开(公告)号:US20210197134A1
公开(公告)日:2021-07-01
申请号:US16071228
申请日:2017-01-19
申请人: GAMBRO LUNDIA AB
发明人: Bernd KRAUSE , Adriana BOSCHETTI-DE-FIERRO , Manuel VOIGT , Johannes GECKELER , Ferdinand SCHWEIGER
摘要: The present disclosure relates to a microporous hollow fiber filter membrane having a large inner diameter and a thin wall. The fiber can be used for sterile filtration of liquids or removal of particles from liquids. The disclosure further relates to a method for producing the membrane and a filter device comprising the membrane.
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公开(公告)号:US20170165616A1
公开(公告)日:2017-06-15
申请号:US15116031
申请日:2015-02-05
申请人: GAMBRO LUNDIA AB
发明人: Adriana BOSCHETTI-DE-FIERRO , Manuel VOIGT , Bernd KRAUSE , Markus HORNUNG , Markus STORR , Heinrich BEHR , Werner BECK , Carina ZWEIGART , Reinhold BUCK , Philipp HERBST , Joachim LOERCHER , Arnd WOCHNER
摘要: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.
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