公开(公告)号：US20220111054A1

公开(公告)日：2022-04-14

申请号：US17483234

申请日：2021-09-23

Applicant: Genentech, Inc.

Inventor： Sandeep Yadav ,  Nidhi Doshi ,  Tamanna Shobha ,  Anthony Tomlinson ,  Amit Srivastava

IPC: A61K47/26

Abstract: The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations. In some embodiments, they may be used in pharmaceutical formulations, for example, to improve stability.

公开(公告)号：US11833206B2

公开(公告)日：2023-12-05

申请号：US17483234

申请日：2021-09-23

Applicant: Genentech, Inc.

Inventor： Sandeep Yadav ,  Nidhi Doshi ,  Tamanna Shobha ,  Anthony Tomlinson ,  Amit Srivastava

IPC: A61K47/26

CPC classification number: A61K47/26

Abstract: The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations. In some embodiments, they may be used in pharmaceutical formulations, for example, to improve stability.

公开(公告)号：US20240050572A1

公开(公告)日：2024-02-15

申请号：US18495374

申请日：2023-10-26

Applicant: Genentech, Inc.

Inventor： Sandeep Yadav ,  Nidhi Doshi ,  Tomanna Shobha ,  Anthony Tomlinson ,  Amit Srivastava

IPC: A61K47/26

CPC classification number: A61K47/26

Abstract: The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations. In some embodiments, they may be used in pharmaceutical formulations, for example, to improve stability.

公开(公告)号：US12098365B2

公开(公告)日：2024-09-24

申请号：US17213611

申请日：2021-03-26

Applicant: GENENTECH, INC.

Inventor： Michael Wilson Laird ,  Shahram Misaghi ,  Amy Shen ,  Anthony Tomlinson ,  Inn Huam Yuk

IPC: C12N15/10 ,  C12N5/071

CPC classification number: C12N15/102 ,  C12N5/0682 ,  C12N2510/00

Abstract: The present disclosure relates to methods, cells, and compositions for producing a product of interest, e.g., a recombinant protein. In particular, the present disclosure provides improved mammalian cells expressing the product of interest, where the cells (e.g., Chinese Hamster Ovary (CHO) cells) have reduced or eliminated activity, e.g., expression, of certain host cell proteins, e.g., enzymes including, but not limited to, certain lipases, esterases, and/or hydrolases.

公开(公告)号：US11865177B2

公开(公告)日：2024-01-09

申请号：US16914100

申请日：2020-06-26

Applicant: Genentech, Inc.

Inventor： Anthony Tomlinson ,  Barthelemy Luc Demeule ,  Isidro Angelo Eleazar Zarraga

IPC: A61K39/395 ,  A61K9/08 ,  A61K9/19 ,  A61K47/22

CPC classification number: A61K39/39591 ,  A61K9/08 ,  A61K9/19 ,  A61K47/22

Abstract: The present disclosure provides liquid formulations comprising polypeptides and surfactants. In particular, it discloses a liquid formulation comprising a polypeptide and a surfactant, wherein at least about 70% (wt %) of the surfactant are isosorbide polyoxyethylene (POE) fatty acid esters. The invention also provides methods for making such liquid formulations, articles of manufacture comprising such liquid formulations and methods of treating a patient with such liquid formulations.