公开(公告)号：US10011654B2

公开(公告)日：2018-07-03

申请号：US14491641

申请日：2014-09-19

Applicant: GENENTECH, INC.

Inventor： David P. Arnott ,  Austin L. Gurney ,  Philip E. Hass ,  James M. Lee ,  Yan Wu

IPC: A61K39/395 ,  C07K16/24 ,  C07K14/54 ,  G01N33/68

CPC classification number: C07K16/244 ,  A61K38/00 ,  C07K14/54 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/6869 ,  Y02A50/463 ,  Y02A50/473

Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

公开(公告)号：US20170042967A1

公开(公告)日：2017-02-16

申请号：US15065777

申请日：2016-03-09

Applicant: GENENTECH, INC.

Inventor： Avi Ashkenazi ,  Karim Yussef Helmy ,  Sherman Fong ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth James Katschke, Jr. ,  Menno Van Lookeren ,  William I. Wood

IPC: A61K38/17 ,  C07K14/705

CPC classification number: A61K38/177 ,  A61K38/17 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/77 ,  C07K2319/30 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.

Abstract translation: 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在补体相关疾病的治疗中的应用。

公开(公告)号：US20130331553A1

公开(公告)日：2013-12-12

申请号：US13734261

申请日：2013-01-04

Applicant: Genentech, Inc.

Inventor： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Melanie R. Mark ,  Ruey-Bing Yang

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K16/2896

Abstract: The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PRO285, PRO286, and PRO358, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO285, or PRO286, or PRO358 Toll protein.

Abstract translation: 本发明涉及鉴定和分离编码人Toll蛋白PRO285，PRO286和PRO358的新型DNA，以及重组生产这些蛋白质的方法和手段。 本发明还涉及特异性结合PRO285或PRO286或PRO358 Toll蛋白的抗体。

公开(公告)号：US20140193332A1

公开(公告)日：2014-07-10

申请号：US14071257

申请日：2013-11-04

Applicant: GENENTECH, INC.

Inventor： Audrey Goddard ,  Austin L. Gurney

IPC: C07K16/28 ,  G01N33/53 ,  C12Q1/68 ,  C07K14/705 ,  A61K51/10

CPC classification number: C07K16/28 ,  A61K47/6843 ,  A61K51/1018 ,  A61K51/1027 ,  C07K14/4713 ,  C07K14/705 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/53 ,  G01N2800/065

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of inflammatory bowel diseases in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于诊断和治疗哺乳动物炎症性肠病的物质组合物，以及使用该物质组合物的方法。

公开(公告)号：US20130309194A1

公开(公告)日：2013-11-21

申请号：US13649810

申请日：2012-10-11

Applicant: GENENTECH, INC.

Inventor： Austin L. Gurney

IPC: A61K39/395

CPC classification number: C07K14/54 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/244 ,  C07K16/2866 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/6869 ,  G01N2500/02

Abstract: The invention concerns inhibition of the production of proinflammatory cytokine interleukin-17 (IL-17) by T cells, using an antagonist of interleukin-23 (IL-23). The invention further concerns the use of IL-23 antagonists in the treatment of inflammatory diseases characterized by the presence of elevated levels of IL-17. IL-23 antagonists include, without limitation, antibodies specifically binding to a subunit or IL-17 or an IL-17 receptor. The invention additionally concerns induction of IL-7 production by using an IL-23 agonist.

Abstract translation: 本发明涉及使用白介素-23（IL-23）拮抗剂对T细胞促炎细胞因子白细胞介素-17（IL-17）的产生的抑制。 本发明还涉及IL-23拮抗剂在治疗特征在于存在升高的IL-17水平的炎性疾病中的用途。 IL-23拮抗剂包括但不限于与亚单位或IL-17或IL-17受体特异性结合的抗体。 本发明还涉及通过使用IL-23激动剂诱导IL-7产生。

公开(公告)号：US20160326229A1

公开(公告)日：2016-11-10

申请号：US15066568

申请日：2016-03-10

Applicant: GENENTECH, INC.

Inventor： Austin L. Gurney

IPC: C07K14/54 ,  C07K16/28 ,  C07K16/24

CPC classification number: C07K14/54 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/244 ,  C07K16/2866 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/6869 ,  G01N2500/02

Abstract: The invention concerns inhibition of the production of proinflammatory cytokine interleukin-17 (IL-17) by T cells, using an antagonist of interleukin-23 (IL-23). The invention further concerns the use of IL-23 antagonists in the treatment of inflammatory diseases characterized by the presence of elevated levels of IL-17. IL-23 antagonists include, without limitation, antibodies specifically binding to a subunit or IL-17 or an IL-17 receptor. The invention additionally concerns induction of IL-7 production by using an IL-23 agonist.

公开(公告)号：US20150166631A1

公开(公告)日：2015-06-18

申请号：US14451764

申请日：2014-08-05

Applicant: GENENTECH, INC.

Inventor： Hilary Clark ,  Daniel L. Eaton ,  Bernd Wranik ,  Wenjun Ouyang ,  Lino Gonzalez ,  Austin L. Gurney

IPC: C07K14/705 ,  C07K16/28 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K16/28 ,  C07K2319/00 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/6893 ,  G01N2333/705 ,  G01N2800/065 ,  G01N2800/24 ,  G01N2800/245

Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.

Abstract translation: 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。