公开(公告)号：US20210087288A1

公开(公告)日：2021-03-25

申请号：US17008941

申请日：2020-09-01

Applicant: Genentech, Inc.

Inventor： Yin Zhang ,  Joy Yu Zuchero ,  Jasvinder Atwal ,  Jessica Couch ,  Mark S. Dennis ,  James A. Ernst ,  Ryan J. Watts ,  Gregory A. Lazar

IPC: C07K16/28 ,  C07K16/40 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

公开(公告)号：US20150110791A1

公开(公告)日：2015-04-23

申请号：US14283038

申请日：2014-05-20

Applicant: GENENTECH, INC.

Inventor： Yin Zhang ,  Joy Yu Zuchero ,  Jasvinder Atwal ,  Jessica Couch ,  Mark S. Dennis ,  James A. Ernst ,  Ryan J. Watts ,  Gregory A. Lazar

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48

CPC classification number: C07K16/2881 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

Abstract translation: 本发明涉及抗转铁蛋白受体抗体及其使用方法。

公开(公告)号：US10808036B2

公开(公告)日：2020-10-20

申请号：US15614149

申请日：2017-06-05

Applicant: Genentech, Inc.

Inventor： Yin Zhang ,  Joy Yu Zuchero ,  Jasvinder Atwal ,  Jessica Couch ,  Mark S. Dennis ,  James A. Ernst ,  Ryan J. Watts ,  Gregory A. Lazar

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/40 ,  A61K47/68 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

公开(公告)号：US20180002433A1

公开(公告)日：2018-01-04

申请号：US15614149

申请日：2017-06-05

Applicant: Genentech, Inc.

Inventor： Yin Zhang ,  Joy Yu Zuchero ,  Jasvinder Atwal ,  Jessica Couch ,  Mark S. Dennis ,  James A. Ernst ,  Ryan J. Watts ,  Gregory A. Lazar

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/40 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

公开(公告)号：US09708406B2

公开(公告)日：2017-07-18

申请号：US14283038

申请日：2014-05-20

Applicant: Genentech, Inc.

Inventor： Yin Zhang ,  Joy Yu Zuchero ,  Jasvinder Atwal ,  Jessica Couch ,  Mark S. Dennis ,  James A. Ernst ,  Ryan J. Watts ,  Gregory A. Lazar

IPC: C07K16/40 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48 ,  A61K39/00

CPC classification number: C07K16/2881 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

公开(公告)号：US20220033520A1

公开(公告)日：2022-02-03

申请号：US17343543

申请日：2021-06-09

Applicant: Genentech, Inc.

Inventor： Gregory A. Lazar ,  James Ernst ,  Jasvinder Atwal ,  Shraddha Shirish Sadekar ,  Yanli Yang ,  Shan Chung

IPC: C07K16/40 ,  A61P25/28 ,  C07K16/18

Abstract: Biological macromolecules have tremendous potential for the treatment of disease of the central nervous system (CNS), however, the presence of the blood brain barrier (BBB) makes achieving a therapeutically relevant antibody concentration extremely challenging. Antibodies with enhanced neutral pH affinity for the neonatal Fc receptor demonstrate improved accumulation in the brain. Variants disclosed herein also enhanced exposure in engineered mouse models. Using an anti-BACE1 antibody, these Fc variants significantly reduced the levels of brain Abeta.