公开(公告)号：US20240046473A1

公开(公告)日：2024-02-08

申请号：US18482697

申请日：2023-10-06

Applicant: Ventana Medical Systems, Inc. ,  Genentech, Inc.

Inventor： Xingwei WANG ,  Auranuch LORSAKUL ,  Zuo ZHAO ,  Yao NIE ,  Hartmut KOEPPEN ,  Hauke KOLSTER ,  Kandavel SHANMUGAM

IPC: G06T7/00 ,  G16H30/40

CPC classification number: G06T7/0012 ,  G16H30/40 ,  G06T2207/20084 ,  G06T2207/20081

Abstract: The present disclosure relates to techniques for obtaining a synthetic immunohistochemistry (IHC) image from a histochemically stained image. Particularly, aspects of the present disclosure are directed to accessing an input image that depicts a tissue section that has been stained with at least one histochemical stain; generating a synthetic image by processing the input image using a trained generator network; and outputting the synthetic image. The synthetic image depicts a tissue section that has been stained with at least one IHC stain that targets a first antigen, and techniques may also include receiving an input that is based on a level of expression of a first antigen from the synthetic image and/or generating, from the synthetic image, a value that is based on a level of expression of the first antigen.

公开(公告)号：US20170183740A1

公开(公告)日：2017-06-29

申请号：US15272283

申请日：2016-09-21

Applicant: Genentech, Inc.

Inventor： Wei YU ,  David SHAMES ,  Hartmut KOEPPEN ,  See PHAN ,  Sandra ROST

IPC: C12Q1/68 ,  C07K16/22 ,  C07K16/28

CPC classification number: C12Q1/6886 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/76 ,  C12Q2600/158

Abstract: The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20160009805A1

公开(公告)日：2016-01-14

申请号：US14726329

申请日：2015-05-29

Applicant: GENENTECH, INC. ,  SPRING BIOSCIENCE CORPORATION ,  VENTANA MEDICAL SYSTEMS, INC.

Inventor： Marcin KOWANETZ ,  Hartmut KOEPPEN ,  Zachary BOYD ,  Zhiming LIAO ,  Yifei ZHU ,  Bharathi VENNAPUSA ,  Patrick C. ROCHE

IPC: C07K16/28 ,  G01N33/574 ,  A61K39/395 ,  C07K14/705 ,  A61K45/06

CPC classification number: C07K16/2827 ,  A61K39/3955 ,  A61K45/06 ,  A61N2005/1021 ,  C07K14/70532 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/53 ,  G01N33/57484 ,  G01N2500/10 ,  G01N2800/52

Abstract: The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same.

Abstract translation: 本发明提供程序性死亡 - 配体1（PD-L1）抗体及其使用方法。

公开(公告)号：US20250164494A1

公开(公告)日：2025-05-22

申请号：US19028633

申请日：2025-01-17

Applicant: Genentech, Inc.

Inventor： Marcin KOWANETZ ,  Daniel Shin-Yu CHEN ,  Hartmut KOEPPEN

IPC: G01N33/574 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  G06Q30/0241 ,  G06Q30/0251

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20220146517A1

公开(公告)日：2022-05-12

申请号：US17403349

申请日：2021-08-16

Applicant: Genentech, Inc.

Inventor： Marcin KOWANETZ ,  Daniel Shin-Yu CHEN ,  Hartmut KOEPPEN

IPC: G01N33/574 ,  C12Q1/6886 ,  G06Q30/02 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20200041520A1

公开(公告)日：2020-02-06

申请号：US16657031

申请日：2019-10-18

Applicant: Genentech, Inc.

Inventor： Marcin KOWANETZ ,  Daniel Shin-Yu CHEN ,  Hartmut KOEPPEN

IPC: G01N33/574 ,  C12Q1/6886 ,  G06Q30/02 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20160222118A1

公开(公告)日：2016-08-04

申请号：US14850462

申请日：2015-09-10

Applicant: GENENTECH, INC.

Inventor： Daniel Shin-Yu CHEN ,  Priti HEGDE ,  Hartmut KOEPPEN ,  Marcin KOWANETZ

IPC: C07K16/28 ,  G01N33/574 ,  G06Q30/02 ,  G01N33/68

CPC classification number: C07K16/2827 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C12Q1/6886 ,  G01N33/57484 ,  G01N33/57492 ,  G01N33/6854 ,  G01N33/6869 ,  G01N2333/5412 ,  G01N2333/70532 ,  G01N2800/52 ,  G06Q30/0251

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20240346804A1

公开(公告)日：2024-10-17

申请号：US18612987

申请日：2024-03-21

Applicant: Genentech, Inc.

Inventor： Jeffrey Ryan EASTHAM ,  Hartmut KOEPPEN ,  Xiao LI ,  Darya Yuryevna ORLOVA

IPC: G06V10/764 ,  G06T7/00 ,  G06V10/25

CPC classification number: G06V10/764 ,  G06T7/0012 ,  G06V10/25 ,  G06T2207/20081 ,  G06T2207/30096

Abstract: Described herein are systems, methods, and programming describing various pipelines for determining an immunophenotype of a tumor depicted by a digital pathology image based on immune cell density in the tumor epithelium and/or the tumor stroma and/or spatial information across all or part of the image. One or more machine learning models may be implemented by some or all of the pipelines. The pipelines may include a first pipeline using density thresholds for immunophenotyping, a second pipeline using immune cell density in tumor epithelium and tumor stroma for immunophenotyping, a third pipeline using spatial information of the digital pathology image for immunophenotyping, and a fourth pipeline that combines aspects of the second and third pipelines for immunophenotyping.

公开(公告)号：US20220363764A1

公开(公告)日：2022-11-17

申请号：US17686628

申请日：2022-03-04

Applicant: Genentech, Inc.

Inventor： Daniel Shin-Yu CHEN ,  Priti HEGDE ,  Hartmut KOEPPEN ,  Marcin KOWANETZ

IPC: C07K16/28 ,  G01N33/574 ,  C12Q1/6886 ,  G01N33/68 ,  G06Q30/02

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

公开(公告)号：US20180313845A1

公开(公告)日：2018-11-01

申请号：US16035238

申请日：2018-07-13

Applicant: Genentech, Inc.

Inventor： Marcin KOWANETZ ,  Daniel Shin-Yu CHEN ,  Hartmut KOEPPEN

IPC: G01N33/574 ,  C07K16/28 ,  C12Q1/6886 ,  G06Q30/02 ,  A61K39/395 ,  A61K45/06

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2827 ,  C07K16/30 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N2333/70532 ,  G06Q30/0241 ,  G06Q30/0251

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.