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公开(公告)号：US11261493B2
公开(公告)日：2022-03-01
申请号：US16845575
申请日：2020-04-10
Applicant: GENENTECH, INC.
Inventor： Jason A. Hackney , Mary Keir , Gaik Wei Tew
IPC: C12Q1/6883 , G01N33/573 , G01N33/53 , C07K16/28 , A61K39/00
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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公开(公告)号：US20150307611A1
公开(公告)日：2015-10-29
申请号：US14675081
申请日：2015-03-31
Applicant: GENENTECH, INC.
Inventor： Mary Keir , Gaik Wei Tew
CPC classification number: C07K16/2839 , C07K2317/24 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6872 , G01N33/6893 , G01N2333/7051 , G01N2333/70546 , G01N2800/06 , G01N2800/065 , G01N2800/52
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
Abstract translation: 提供了预测对整合素β7拮抗剂（包括抗β7整联蛋白亚单位抗体）的反应性的生物标志物和使用这些生物标志物的方法。 此外，提供了治疗胃肠道炎症性疾病如包括溃疡性结肠炎和克罗恩病的炎症性肠病的方法。 还提供了使用这种预测性生物标志物治疗包括溃疡性结肠炎和克罗恩病的炎症性肠病的方法。
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公开(公告)号：US09873742B2
公开(公告)日：2018-01-23
申请号：US14675081
申请日：2015-03-31
Applicant: Genentech, Inc.
Inventor： Mary Keir , Gaik Wei Tew
CPC classification number: C07K16/2839 , C07K2317/24 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6872 , G01N33/6893 , G01N2333/7051 , G01N2333/70546 , G01N2800/06 , G01N2800/065 , G01N2800/52
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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公开(公告)号：US20160178644A1
公开(公告)日：2016-06-23
申请号：US14944147
申请日：2015-11-17
Applicant: GENENTECH, INC.
Inventor： Jason A. Hackney , Mary Keir , Lilyan Yi Tian Wright
CPC classification number: G01N33/6893 , C07K16/244 , C12Q1/6883 , C12Q2600/158 , G01N2800/065
Abstract: Biomarkers for diagnosing inflammatory bowel disease, including Crohn's disease, including fibrotic or fibrostenotic Crohn's disease, and ulcerative colitis and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease, including fibrotic or fibrostenotic Crohn's disease, are provided.
Abstract translation: 用于诊断炎症性肠病的生物标志物，包括克罗恩病，包括纤维化或纤维化克罗恩病，以及溃疡性结肠炎和使用这种生物标志物的方法。 此外，提供了治疗消化道炎症性疾病如包括溃疡性结肠炎和克罗恩病在内的炎性肠病，包括纤维化或纤维化克罗恩病的方法。
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公开(公告)号：US20190256913A1
公开(公告)日：2019-08-22
申请号：US16295536
申请日：2019-03-07
Applicant: GENENTECH, INC.
Inventor： Jason A. Hackney , Mary Keir , Gaik Wei Tew
IPC: C12Q1/6883 , C07K16/28
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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Patent Agency Ranking
公开(公告)号：US10273542B2
公开(公告)日：2019-04-30
申请号：US15271687
申请日：2016-09-21
Applicant: Genentech, Inc.
Inventor： Jason A. Hackney , Mary Keir , Gaik Wei Tew
IPC: C12Q1/68 , G01N33/53 , C12Q1/6883 , C07K16/28 , A61K39/00
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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公开(公告)号：US20170233809A1
公开(公告)日：2017-08-17
申请号：US15271687
申请日：2016-09-21
Applicant: Genentech, Inc.
Inventor： Jason A. Hackney , Mary Keir , Gaik Wei Tew
CPC classification number: C12Q1/6883 , A61K2039/505 , C07K16/2839 , C07K16/2842 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C12Q2600/106 , C12Q2600/158
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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公开(公告)号：US20220186314A1
公开(公告)日：2022-06-16
申请号：US17580357
申请日：2022-01-20
Applicant: GENENTECH, INC.
Inventor： Jason A. Hackney , Mary Keir , Gaik Wei Tew
IPC: C12Q1/6883 , G01N33/573 , G01N33/53
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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公开(公告)号：US20200325538A1
公开(公告)日：2020-10-15
申请号：US16845575
申请日：2020-04-10
Applicant: GENENTECH, INC.
Inventor： Jason A. Hackney , Mary Keir , Gaik Wei Tew
IPC: C12Q1/6883 , C07K16/28
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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公开(公告)号：US10669587B2
公开(公告)日：2020-06-02
申请号：US16295536
申请日：2019-03-07
Applicant: GENENTECH, INC.
Inventor： Jason A. Hackney , Mary Keir , Gaik Wei Tew
IPC: C12Q1/6883 , C07K16/28 , A61K39/00
Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
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