公开(公告)号：US20180169259A1

公开(公告)日：2018-06-21

申请号：US15628813

申请日：2017-06-21

Applicant: Genentech Inc.

Inventor： Paul Polakis ,  Andrew Polson ,  Susan Diane Spencer ,  Shang-Fan Yu

IPC: A61K47/68 ,  A61K45/06 ,  A61K31/551

CPC classification number: A61K47/6813 ,  A61K31/551 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867 ,  A61K2300/00

Abstract: The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20170002074A1

公开(公告)日：2017-01-05

申请号：US15171128

申请日：2016-06-02

Applicant: GENENTECH, INC.

Inventor： Shang-Fan Yu ,  Wei-Ching Liang ,  Yan Wu ,  Steven Leong ,  Andrew Polson

IPC: C07K16/28 ,  G01N33/574 ,  A61K47/48

CPC classification number: C07K16/2803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/70596 ,  G01N2458/00

Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.

Abstract translation: 本发明提供抗CD33抗体和免疫缀合物及其使用方法。

公开(公告)号：US20140030282A1

公开(公告)日：2014-01-30

申请号：US13936285

申请日：2013-07-08

Applicant: Genentech, Inc.

Inventor： Paul Polakis ,  Andrew Polson ,  Susan Diane Spencer ,  Shang-Fan Yu ,  Bing Zheng

IPC: A61K47/48 ,  A61K45/06 ,  A61K31/706

CPC classification number: A61K47/6809 ,  A61K31/706 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6867

Abstract: The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.

Abstract translation: 本发明提供抗CD79b抗体和免疫缀合物及其使用方法。

公开(公告)号：US20250122280A1

公开(公告)日：2025-04-17

申请号：US18927265

申请日：2024-10-25

Applicant: Genentech, Inc.

Inventor： Nicholas John Agard ,  Thomas Harden Pillow ,  Josefa Dela Cruz Chuh ,  Mary Ann T. Go ,  Katherine R. Kozak ,  Zhonghua Lin ,  Dhaya Seshasayee ,  Shang-Fan Yu ,  James Thomas Koerber ,  Yonglian Sun

IPC: C07K16/28 ,  A61K45/06 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  G01N33/574 ,  G01N33/68

Abstract: The invention provides anti-Ly6E antibodies and immunoconjugates, and methods of using the same.

公开(公告)号：US20180312586A1

公开(公告)日：2018-11-01

申请号：US15918842

申请日：2018-03-12

Applicant: GENENTECH, INC.

Inventor： Shang-Fan Yu ,  Wei-Ching Liang ,  Yan Wu ,  Steven Leong ,  Andrew Polson

IPC: C07K16/28 ,  A61K47/68 ,  G01N33/574 ,  A61K39/00

Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10017577B2

公开(公告)日：2018-07-10

申请号：US15181618

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： Paul Polakis ,  Peter Dragovich ,  Thomas Harden Pillow ,  Shang-Fan Yu

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3092 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/515

Abstract: The invention provides immunoconjugates and methods of using the same.

公开(公告)号：US12016842B2

公开(公告)日：2024-06-25

申请号：US17230861

申请日：2021-04-14

Applicant: Genentech, Inc.

Inventor： Andrew Polson ,  Shang-Fan Yu ,  Yu-Waye Chu ,  Michael Wenger ,  Jamie Harue Hirata ,  Dan Lu

IPC: A61K39/00 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/553 ,  A61K31/635 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30

CPC classification number: A61K31/4184 ,  A61K31/454 ,  A61K31/553 ,  A61K31/635 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6889 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/3061 ,  A61K2039/507 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2300/00 ,  C07K2317/24 ,  A61K39/39558 ,  A61K2300/00 ,  A61K31/4184 ,  A61K2300/00 ,  A61K31/635 ,  A61K2300/00 ,  A61K31/454 ,  A61K2300/00 ,  A61K31/553 ,  A61K2300/00 ,  A61K39/3955 ,  A61K2300/00

Abstract: Provided herein are methods of treating B-cell proliferative disorders in particular Follicular Lymphoma and/or Diffuse Large B-Cell Lymphoma using immunoconjugates comprising anti-CD79b antibodies in combination with additional therapeutic agents.

公开(公告)号：US20150098946A1

公开(公告)日：2015-04-09

申请号：US14400684

申请日：2013-03-14

Applicant: Genentech, Inc.

Inventor： Sunil Bhakta ,  Meredith Hazen ,  Jo-Anne S Hongo ,  Jagath R Junutula ,  Isidro Hotzel ,  Yonglei Shang ,  Shang-Fan Yu

IPC: C07K16/30 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6817 ,  A61K47/6855 ,  A61K51/1051 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/77 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415 ,  G01N33/57423 ,  G01N2333/47 ,  G01N2500/02

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.

Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。 在某些方面，分离的核酸分子包含具有至少约80％核酸序列同一性，或至少约81％，82％，83％，84％，85％，86％，87％，88 ％，89％，90％，91％，92％，93％，94％，95％，96％，97％，98％，99％或100％的核酸序列同一性。 如本文公开的具有本文公开的氨基酸序列的全长TAT多肽，缺乏本文公开的信号肽的TAT多肽氨基酸序列，跨膜TAT多肽的胞外结构域，具有或不具有信号肽。

公开(公告)号：US20140030280A1

公开(公告)日：2014-01-30

申请号：US13936280

申请日：2013-07-08

Applicant: Genentech, Inc.

Inventor： Paul Polakis ,  Andrew Polson ,  Susan Diane Spencer ,  Shang-Fan Yu

IPC: A61K47/48 ,  A61K45/06 ,  A61K31/551

CPC classification number: A61K47/6813 ,  A61K31/551 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867 ,  A61K2300/00

Abstract: The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20180015179A1

公开(公告)日：2018-01-18

申请号：US15632724

申请日：2017-06-26

Applicant: Genentech, Inc.

Inventor： Paul Polakis ,  Andrew G. Polson ,  Susan Diane Spencer ,  Shang-Fan Yu ,  Bing Zheng

IPC: A61K45/06 ,  A61K31/706

CPC classification number: A61K47/6809 ,  A61K31/706 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6867

Abstract: The invention provides anti-CD79b antibodies and immunoconjugates and methods of using the same.