公开(公告)号：US20140199327A1

公开(公告)日：2014-07-17

申请号：US14211270

申请日：2014-03-14

Applicant: Genentech, Inc.

Inventor： Vishva M. Dixit ,  Dorothy M. French ,  Heather L. Maecker ,  Samuel A. Williams

IPC: G01N33/50

CPC classification number: G01N33/502 ,  G01N33/5011 ,  G01N33/5073 ,  G01N2333/948

Abstract: Provided herein are methods of promoting cell fate change, particularly differentiation of tumor cells, by inhibition of USP1, UAF1, and/or ID (e.g., ID1, ID2, and/or ID3).

Abstract translation: 本文提供通过抑制USP1，UAF1和/或ID（例如，ID1，ID2和/或ID3）促进细胞命运变化，特别是肿瘤细胞分化的方法。

公开(公告)号：US12006331B2

公开(公告)日：2024-06-11

申请号：US17862963

申请日：2022-07-12

Applicant: GENENTECH, INC.

Inventor： Samantha Alyson Green ,  Jessica Marie Grandner ,  Steven Thomas Staben ,  Neri Amara ,  Vishva M. Dixit ,  Elisia Villemure

IPC: C07D498/04 ,  A61K9/08 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D498/04 ,  A61K9/08 ,  A61K9/12 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides a compound of formula (I):




or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 have any of the values described in the specification, as well as compositions comprising a compound of formula (I) or a prodrug thereof, or a pharmaceutically acceptable salt thereof. The compounds are agonists of glycolytic enzyme phosphofructokinase-1 liver type and are useful for treating diseases associated with the activity of glycolytic enzyme phosphofructokinase-1 liver type, such as cancer, diabetes, sepsis, and septic shock.