公开(公告)号：US20150284458A1

公开(公告)日：2015-10-08

申请号：US14743933

申请日：2015-06-18

Applicant: GENENTECH, INC.

Inventor： Yvonne M. CHEN ,  Henry B. LOWMAN ,  Yves MULLER

IPC: C07K16/22 ,  C07K16/00

CPC classification number: C07K16/22 ,  A61K38/00 ,  B65H2801/87 ,  C07K16/00 ,  C07K16/005 ,  C07K16/24 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.