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公开(公告)号：US10316084B2
公开(公告)日：2019-06-11
申请号：US15363045
申请日：2016-11-29
Applicant: GENENTECH, INC.
Inventor： Andrew G. Polson , Weiguang Mao , Ron Firestein
IPC: C07K16/28 , C07K16/30 , G01N33/574 , G01N33/58 , A61K39/395 , A61K39/00
Abstract: The invention provides anti-LgR5 antibodies and methods of using the same.
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公开(公告)号：US20190248889A1
公开(公告)日：2019-08-15
申请号：US16390757
申请日：2019-04-22
Applicant: GENENTECH, INC.
Inventor： Andrew G. Polson , Weiguang Mao , Ron Firestein
IPC: C07K16/28 , G01N33/574 , C07K16/30
CPC classification number: C07K16/28 , A61K39/39558 , A61K2039/5152 , C07K16/3046 , C07K2317/56 , C07K2317/565 , C07K2317/70 , G01N33/574 , G01N33/57492 , G01N2800/52
Abstract: The invention provides anti-LgR5 antibodies and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US09175089B2
公开(公告)日：2015-11-03
申请号：US13853620
申请日：2013-03-29
Applicant: GENENTECH INC.
Inventor： Jo-Anne Hongo , Weiguang Mao , Paul Polakis , Andrew Polson , Rajesh Vij , Yan Wu , Wei-Ching Liang
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/92 , G01N33/6893
Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗LgR5抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20160102146A1
公开(公告)日：2016-04-14
申请号：US14856731
申请日：2015-09-17
Applicant: GENENTECH, INC.
Inventor： Jo-Anne Hongo , Weiguang Mao , Paul Polakis , Andrew Polson , Rajesh Vij , Yan Wu , Wei-Ching Liang
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/92 , G01N33/6893
Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20170166635A1
公开(公告)日：2017-06-15
申请号：US15346532
申请日：2016-11-08
Applicant: GENENTECH, INC.
Inventor： Weiguang Mao , Jagath Reddy Junutula , Paul Polakis
IPC: C07K16/28 , C07K16/30 , G01N33/574 , A61K38/05 , A61K39/395
CPC classification number: C07K16/28 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/40 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492
Abstract: Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p (I) where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
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公开(公告)号：US20170233471A1
公开(公告)日：2017-08-17
申请号：US15363045
申请日：2016-11-29
Applicant: GENENTECH, INC.
Inventor： Andrew G. Polson , Weiguang Mao , Ron Firestein
IPC: C07K16/28 , G01N33/574
CPC classification number: C07K16/28 , C07K16/3046 , C07K2317/56 , C07K2317/565 , C07K2317/70 , G01N33/57492 , G01N2800/52
Abstract: The invention provides anti-LgR5 antibodies and methods of using the same.
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公开(公告)号：US20130336885A1
公开(公告)日：2013-12-19
申请号：US13853620
申请日：2013-03-29
Applicant: GENENTECH INC.
Inventor： Jo-Anne Hongo , Weiguang Mao , Paul Polakis , Andrew Polson , Rajesh Vij , Yan Wu , Wei-Ching Liang
IPC: C07K16/30 , G01N33/68 , A61K51/10 , A61K39/395
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/92 , G01N33/6893
Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗LgR5抗体和免疫缀合物及其使用方法。
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