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公开(公告)号：US20230041134A1
公开(公告)日：2023-02-09
申请号：US17720717
申请日：2022-04-14
申请人： Genentech, Inc.
发明人： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC分类号： C07K16/32 , A61K47/68 , A61K39/395 , C07K16/28 , G01N33/574 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K49/00 , C07K16/30
摘要： The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20190177429A1
公开(公告)日：2019-06-13
申请号：US16170819
申请日：2018-10-25
申请人： Genentech, Inc.
发明人： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC分类号： C07K16/32 , G01N33/574 , A61K49/00 , A61K39/395 , A61K31/704 , A61K31/675 , A61K31/5517 , C07K16/30 , A61K47/68 , C07K16/28
摘要： The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20170362318A1
公开(公告)日：2017-12-21
申请号：US15406583
申请日：2017-01-13
申请人： GENENTECH, INC.
发明人： Craig Crowley , Frederic J. De Sauvage , Dan L. Eaton , Allen Ebens, JR. , Kristi Elkins , Jo-Anne S. Hongo , Jagath Reddy Junutula , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen , Bing Zheng
IPC分类号： C07K16/28 , G01N33/574 , C07K16/30 , A61K47/68 , C07K14/705 , A61K38/00 , A61K39/00
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US10179820B2
公开(公告)日：2019-01-15
申请号：US15296454
申请日：2016-10-18
申请人： Genentech, Inc.
发明人： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC分类号： C07K16/32 , A61K39/395 , C07K16/28 , G01N33/574 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K49/00 , C07K16/30 , A61K47/68
摘要： The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20180201679A1
公开(公告)日：2018-07-19
申请号：US15803495
申请日：2017-11-03
申请人： GENENTECH, INC.
发明人： Yvonne Chen , Mark Dennis , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
CPC分类号： C07K16/2803 , A61K39/39541 , A61K39/39558 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y02A50/412
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20180000962A1
公开(公告)日：2018-01-04
申请号：US15592072
申请日：2017-05-10
申请人： Genentech, Inc.
发明人： Charles W. Eigenbrot, JR. , Jagath Reddy Junutula , Henry Lowman , Helga E. Raab , Richard Vandlen
CPC分类号： A61K47/6803 , A01K2267/0331 , A61K45/06 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/51 , C07K2317/52 , C07K2317/55 , C07K2317/624
摘要： Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab), optionally with an albumin-binding peptide (ABP) sequence, are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
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公开(公告)号：US20170174782A1
公开(公告)日：2017-06-22
申请号：US15296454
申请日：2016-10-18
申请人： Genentech, Inc.
发明人： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC分类号： C07K16/32 , C07K16/30 , A61K31/675 , A61K31/704 , A61K31/5517 , G01N33/574 , A61K49/00
CPC分类号： C07K16/32 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K39/3955 , A61K47/68 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K47/6863 , A61K49/00 , C07K16/2863 , C07K16/3015 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/57415 , G01N33/57446 , G01N33/57492 , G01N2333/82
摘要： The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20160096893A1
公开(公告)日：2016-04-07
申请号：US14851001
申请日：2015-09-11
申请人： Genentech, Inc.
发明人： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC分类号： C07K16/28 , A61K39/395 , G01N33/574 , A61K47/48
CPC分类号： C07K16/32 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K39/3955 , A61K47/68 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K47/6863 , A61K49/00 , C07K16/2863 , C07K16/3015 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/57415 , G01N33/57446 , G01N33/57492 , G01N2333/82
摘要： The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
摘要翻译： 本发明提供抗HER2抗体和免疫缀合物及其使用方法。
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公开(公告)号：US10544218B2
公开(公告)日：2020-01-28
申请号：US15349964
申请日：2016-11-11
申请人： Genentech, Inc.
发明人： Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
IPC分类号： A61K39/395 , A61K39/40 , A61K39/42 , C07K16/28 , A61K38/05 , A61K31/537 , C07K16/30 , A61K51/10 , G01N33/574 , A61K45/06 , A61K47/68 , C07K16/00 , C12P21/08 , A61K39/00
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20190276550A9
公开(公告)日：2019-09-12
申请号：US13973669
申请日：2013-08-22
申请人： Genentech, Inc.
发明人： Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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