公开(公告)号：US20180250666A1

公开(公告)日：2018-09-06

申请号：US15755088

申请日：2016-08-25

Applicant: General Electric Company

Inventor： Praveen Paul ,  Manoj Ramakrishna ,  Anoop Bhargav ,  Haresh Digambar Patil ,  Sebastian John ,  Manish Uddhaorao Choudhary ,  Pradeep Kumar ,  Nivedita Phadke

IPC: B01L1/02 ,  B01L7/02 ,  B01L7/04

CPC classification number: B01L1/025 ,  B01L7/02 ,  B01L7/04 ,  B01L2300/043 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0809 ,  B01L2300/123 ,  B01L2300/18 ,  C12M27/16 ,  C12M41/12 ,  C12M41/14 ,  C12M41/48

Abstract: Disclosed is biomanufacturing apparatus (1) comprising a housing (20), a substantially enclosed bioreactor chamber (30) inside the housing and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40) for supporting a bioreactor, a tray support (45) including a mechanism (44,47) for rocking the tray in use the tray (40) including a heater (42) for contacting a bioreactor and heating the same, and the apparatus further comprising secondary heating (53) for heating air surrounding the tray.

公开(公告)号：US20180002655A1

公开(公告)日：2018-01-04

申请号：US15545395

申请日：2016-01-29

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Haresh Digambar Patil ,  Manoj Ramakrishna ,  Anoop Bhargav ,  Praveen Paul ,  Sebastian John ,  Swapnil Puranik

IPC: C12M1/36 ,  C12M3/06 ,  C12M1/12 ,  C12M1/00 ,  C12N5/071

CPC classification number: C12M41/48 ,  B01F11/0017 ,  B01F15/0085 ,  C12M23/04 ,  C12M23/14 ,  C12M23/38 ,  C12M23/52 ,  C12M27/16 ,  C12M29/10 ,  C12M41/12 ,  C12M41/14 ,  C12N5/0602 ,  C12N2523/00 ,  C12N2527/00

Abstract: The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.

公开(公告)号：US20190388855A1

公开(公告)日：2019-12-26

申请号：US16474376

申请日：2017-12-22

Applicant: General Electric Company

Inventor： Manoj Ramakrishna ,  Sebastian John ,  Anoop Bhargav ,  Haresh Digambar Patil ,  Praveen Paul

IPC: B01F15/00 ,  B01F13/10

Abstract: The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.

公开(公告)号：US20190017011A1

公开(公告)日：2019-01-17

申请号：US15755084

申请日：2016-08-25

Applicant: General Electric Company

Inventor： Haresh Digambar Patil ,  Praveen Paul ,  Manish Uddhaorao Choudhary ,  Pradeep Kumar ,  Anoop Bhargav ,  Sebastian John ,  Nivedita Phadke ,  Manoj Ramakrishna

IPC: C12M1/00 ,  C12M3/00 ,  C12M1/12

Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.

公开(公告)号：US20180251715A1

公开(公告)日：2018-09-06

申请号：US15755087

申请日：2016-08-25

Applicant: General Electric Company

Inventor： Praveen Paul ,  Manoj Ramakrishna ,  Anoop Bhargav ,  Haresh Digambar Patil ,  Sebastian John ,  Manish Uddhaorao Choudhary ,  Pradeep Kumar ,  Nivedita Phadke

IPC: C12M3/06 ,  C12M1/34 ,  C12M1/00 ,  C12M1/107

CPC classification number: C12M27/16 ,  C12M21/04 ,  C12M23/14 ,  C12M23/26 ,  C12M29/10 ,  C12M41/12 ,  C12M41/14

Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.