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1.发明申请公开(公告)号：US20190151299A1
公开(公告)日：2019-05-23
申请号：US16308859
申请日：2017-06-08
发明人： Fei SUN , Lifang WU , Charles Z. DING , Guoping HU , Jian LI , Shuhui CHEN , Jianyu LU
IPC分类号： A61K31/4439 , A61P35/00
摘要： A benzotriazole-derived α and β-unsaturated amide compound used as TGF-βR1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).
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公开(公告)号：US20230174524A1
公开(公告)日：2023-06-08
申请号：US18000684
申请日：2021-06-17
发明人： Peng LI , Chong SU , Xiaolin LI , Zhi LUO , Haiying HE , Guoping HU , Jian LI , Shuhui CHEN
IPC分类号： C07D417/04 , A61P27/04
CPC分类号： C07D417/04 , A61P27/04
摘要： An aminopyridine compound that may be used as an aldehyde trapping agent, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240109861A1
公开(公告)日：2024-04-04
申请号：US18270317
申请日：2021-12-30
发明人： Kevin X CHEN , Li ZHANG , Houze GUI , Haoyu ZHANG , Huiyu ZHANG , Guoping HU , Jian LI , Shuhui CHEN
IPC分类号： C07D401/06 , A61P13/12 , C07D405/14
CPC分类号： C07D401/06 , A61P13/12 , C07D405/14
摘要： A series of piperidine-substituted benzoic acid compounds and the use thereof, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20230357272A1
公开(公告)日：2023-11-09
申请号：US17906762
申请日：2021-04-06
发明人： Shuhui CHEN , Kevin X CHEN , Kai ZHOU , Wen JIANG , Guoping HU , Jian LI
IPC分类号： C07D498/22 , C07D471/22 , A61P35/00
CPC分类号： C07D498/22 , C07D471/22 , A61P35/00
摘要： Disclosed is a class of octahydropyrazinodiazanaphthyridine dione compounds, and specifically disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210371411A1
公开(公告)日：2021-12-02
申请号：US16962951
申请日：2019-01-18
发明人： Yaxian CAI , Zhaobing XU , Hailong YANG , Shiqi HAN , Guoping HU , Lihong HU , Charles Z. DING , Jian LI , Shuhui CHEN
IPC分类号： C07D471/04 , C07D519/00 , A61P35/00
摘要： Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210371395A1
公开(公告)日：2021-12-02
申请号：US16766510
申请日：2018-11-23
发明人： Jinping LI , Xiongbin XU , Gang LI , Lihong HU , Charles Z. DING , Yaling ZHOU , Guoping HU , Jian LI , Shuhui CHEN
IPC分类号： C07D401/12 , A61P35/00 , C07D405/14 , C07D487/04 , C07D401/14
摘要： Provided are a uracil compound represented by Formula (IV) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition of the same. Also provided is a use thereof as a c-MET/AXL inhibitor in preparing a c-MET/AXL-inhibiting drug or a drug for treating a tumor.
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公开(公告)号：US20210147418A1
公开(公告)日：2021-05-20
申请号：US17159928
申请日：2021-01-27
发明人： Yaxian CAI , Zhaobing XU , Hailong YANG , Shiqi HAN , Guoping HU , Lihong HU , Charles Z. DING , Jian LI , Shuhui CHEN
IPC分类号： C07D471/04 , A61P35/00 , C07D519/00
摘要： Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20180222886A1
公开(公告)日：2018-08-09
申请号：US15750704
申请日：2016-08-03
发明人： Shuhui CHEN , Zhengxia CHEN , Meibi DAI , Cheng XIE , Peng LI , Yang ZHANG , Guibai LIANG , Qiang WANG , Jiangpeng LIAO , Fei SUN , Guoping HU , Jian LI
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D413/14 , A61P35/00
摘要： FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.
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公开(公告)号：US20230055321A1
公开(公告)日：2023-02-23
申请号：US17778533
申请日：2020-11-20
发明人： Kevin X CHEN , Shanghua XIA , Zhaoguo CHEN , Zuhao GUO , Yanxin YU , Kai ZHOU , Boyu HU , Li ZHANG , Fen JIANG , Jingjing WANG , Guoping HU , Jian LI , Shuhui CHEN
IPC分类号： A61K31/519 , C07D519/00 , A61K45/06 , A61K31/55
摘要： Provided are a class of DNA-PK inhibitor, and specifically, a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of DNA-PK inhibitor-related drugs.
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公开(公告)号：US20220281868A1
公开(公告)日：2022-09-08
申请号：US17629117
申请日：2020-07-23
发明人： Yaxian CAI , Xiaobing YAN , Zhe CAI , Guoping HU , Charles Z. DING , Kevin X CHEN , Jian LI , Shuhui CHEN
IPC分类号： C07D471/18 , A61P7/02
摘要： Macrocyclic derivatives, preparation methods therefor and pharmaceutical compositions comprising said derivatives, and uses thereof as therapeutic agents, especially as factor XIa inhibitors and in drugs for treating and preventing thromboembolisms and other diseases. Specifically disclosed is a compound represented by formula (I), and an isomer and pharmaceutically acceptable salt thereof.
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