公开(公告)号：US20190151299A1

公开(公告)日：2019-05-23

申请号：US16308859

申请日：2017-06-08

申请人： GENFLEET THERAPEUTICS (SHANGHAI) INC. ,  MEDSHINE DISCOVERY INC.

发明人： Fei SUN ,  Lifang WU ,  Charles Z. DING ,  Guoping HU ,  Jian LI ,  Shuhui CHEN ,  Jianyu LU

IPC分类号： A61K31/4439 ,  A61P35/00

摘要： A benzotriazole-derived α and β-unsaturated amide compound used as TGF-βR1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).

公开(公告)号：US20210079021A1

公开(公告)日：2021-03-18

申请号：US16771977

申请日：2018-12-13

申请人： GENFLEET THERAPEUTICS (SHANGHAI) INC.

发明人： Lifang WU ,  Huijun HE ,  Jianyu LU ,  Charles Z. DING ,  Lihong HU ,  Weidong LI ,  Shenyi SHI ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D519/00

摘要： Disclosed in the present invention are a crystal form and salt form of a TGF-βR1 inhibitor and a preparation method therefor, and further disclosed is an application of the crystal form and the salt form in preparation of medicines for treating cancers.

公开(公告)号：US20240109861A1

公开(公告)日：2024-04-04

申请号：US18270317

申请日：2021-12-30

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Li ZHANG ,  Houze GUI ,  Haoyu ZHANG ,  Huiyu ZHANG ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D401/06 ,  A61P13/12 ,  C07D405/14

CPC分类号： C07D401/06 ,  A61P13/12 ,  C07D405/14

摘要： A series of piperidine-substituted benzoic acid compounds and the use thereof, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230365558A1

公开(公告)日：2023-11-16

申请号：US18245551

申请日：2021-09-18

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X CHEN ,  Zuhao GUO ,  Yanxin YU ,  Boyu HU ,  Jingjing WANG ,  Zhaoguo CHEN ,  Cheng XIE ,  Jian XIONG ,  Yongbo FANG ,  Yingtao LIU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  C07D413/12 ,  C07D498/04 ,  C07D498/10 ,  C07D401/12 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D413/12 ,  C07D498/04 ,  C07D498/10 ,  C07D401/12 ,  A61P35/00 ,  C07B2200/13

摘要： A series of tetrahydroisoquinoline derivatives and the crystal forms thereof. Specifically disclosed are a compound as represented by formula (VII), a crystal form thereof, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230357272A1

公开(公告)日：2023-11-09

申请号：US17906762

申请日：2021-04-06

申请人： MEDSHINE DISCOVERY INC.

发明人： Shuhui CHEN ,  Kevin X CHEN ,  Kai ZHOU ,  Wen JIANG ,  Guoping HU ,  Jian LI

IPC分类号： C07D498/22 ,  C07D471/22 ,  A61P35/00

CPC分类号： C07D498/22 ,  C07D471/22 ,  A61P35/00

摘要： Disclosed is a class of octahydropyrazinodiazanaphthyridine dione compounds, and specifically disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230128137A1

公开(公告)日：2023-04-27

申请号：US17910536

申请日：2021-03-08

申请人： MEDSHINE DISCOVERY INC.

发明人： Hongjian WANG ,  Wenyuan QIAN ,  Ming ZHANG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  A61P35/00

摘要： A benzo five-membered cyclic compound represented by formula (I) or a pharmaceutically acceptable salt thereof has a significant effect in inhibiting the activity of anti-apoptotic Bcl-2 protein.

公开(公告)号：US20230094146A1

公开(公告)日：2023-03-30

申请号：US17790985

申请日：2021-01-07

申请人： MEDSHINE DISCOVERY INC.

发明人： Zhifei FU ,  Miaorong LUO ,  Yang ZHANG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D495/04

摘要： Disclosed is a deuterated thienopyridine compound. Specifically disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220112217A1

公开(公告)日：2022-04-14

申请号：US17270372

申请日：2019-08-21

申请人： MEDSHINE DISCOVERY INC.

发明人： Chengde WU ,  Jingjie HUANG ,  Tao YU ,  Jie LI ,  Zhen GONG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D519/00 ,  A61P35/00

摘要： A series of pyrazolopyrimidine derivatives can be used in preparing a medicament for treating a disease related to PI3K. For example, a compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof are effective in treating a disease related to P13K.

公开(公告)号：US20210380599A1

公开(公告)日：2021-12-09

申请号：US17280538

申请日：2019-09-27

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan QIAN ,  Chundao YANG ,  Guoqiang DAI ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D491/20 ,  A61K31/7048 ,  A61P35/00 ,  C07D471/04 ,  C07D471/20

摘要： Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.

公开(公告)号：US20210371411A1

公开(公告)日：2021-12-02

申请号：US16962951

申请日：2019-01-18

申请人： MEDSHINE DISCOVERY INC.

发明人： Yaxian CAI ,  Zhaobing XU ,  Hailong YANG ,  Shiqi HAN ,  Guoping HU ,  Lihong HU ,  Charles Z. DING ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61P35/00

摘要： Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.