公开(公告)号：US11512137B2

公开(公告)日：2022-11-29

申请号：US16872140

申请日：2020-05-11

Applicant: GENMAB HOLDING B.V.

Inventor： Simone Oostindie ,  Frank Beurskens ,  Esther Breij ,  Edward Van Den Brink ,  Andreas Hollenstein ,  Marije Overdijk ,  Margaret Lindorfer ,  Ronald Taylor ,  Paul Parren ,  Hilma Van Der Horst ,  Martine E. D. Chamuleau ,  Tuna Mutis

IPC: C07K16/28 ,  A61P35/00 ,  A61K49/00 ,  G01N33/68 ,  A61K39/00

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.

公开(公告)号：US11034772B2

公开(公告)日：2021-06-15

申请号：US17066190

申请日：2020-10-08

Applicant: GENMAB HOLDING B.V.

Inventor： Simone Oostindie ,  Frank Beurskens ,  Esther Breij ,  Edward Van Den Brink ,  Andreas Hollenstein ,  Marije Overdijk ,  Margaret Lindorfer ,  Ronald Taylor ,  Paul Parren ,  Hilma Van Der Horst ,  Martine E. D. Chamuleau ,  Tuna Mutis

IPC: C07K16/28 ,  A61P35/00 ,  A61K49/00 ,  G01N33/68 ,  A61K39/00

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.

公开(公告)号：US10544220B2

公开(公告)日：2020-01-28

申请号：US15541594

申请日：2016-01-08

Applicant: GENMAB A/S

Inventor： Patrick Engelberts ,  Esther Breij ,  Rik Rademaker ,  Isil Altintas ,  David Satijn ,  Sandra Verploegen ,  Riemke Van Dijkhuizen Radersma ,  Edward Van Den Brink ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

Abstract: Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired.

公开(公告)号：US10465006B2

公开(公告)日：2019-11-05

申请号：US14902757

申请日：2014-07-04

Applicant: GENMAB

Inventor： Edward Van Den Brink ,  Joost J. Neijssen ,  Aran Frank Labrijn ,  Joyce Meesters ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/28 ,  C07K16/10 ,  C07K16/32 ,  C07K16/42 ,  G01N33/68 ,  A61K39/00

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.