公开(公告)号：US11878965B2

公开(公告)日：2024-01-23

申请号：US17557860

申请日：2021-12-21

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Zhenhong R. Cai ,  Eda Y. Canales ,  Laurent P. Debien ,  Timothy R. Hansen ,  Richard Huang ,  Petr Jansa ,  Rick A. Lee ,  Jennifer A. Loyer-Drew ,  Ryan McFadden ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Roland D. Saito ,  Michael S. Sangi ,  Adam J. Schrier ,  Marina E. Shatskikh ,  James G. Taylor ,  Joshua J. Van Veldhuizen ,  Lianhong Xu

IPC: C07D401/04 ,  A61K31/437 ,  A61K31/454 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5383 ,  A61K45/06 ,  C07D401/14 ,  C07D519/00

CPC classification number: C07D401/04 ,  A61K31/437 ,  A61K31/454 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5383 ,  A61K45/06 ,  C07D401/14 ,  C07D519/00

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

公开(公告)号：US11851419B2

公开(公告)日：2023-12-26

申请号：US17530300

申请日：2021-11-18

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas J. Brizgys ,  James S. Cassidy ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang

IPC: C07D401/14 ,  A61K45/06 ,  C07D405/14

CPC classification number: C07D401/14 ,  A61K45/06 ,  C07D405/14

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20230391747A1

公开(公告)日：2023-12-07

申请号：US18195767

申请日：2023-05-10

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Gediminas J. Brizgys ,  James S. Cassidy ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Michael Graupe ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Daniel G. Shore ,  Suzanne M. Szewczyk ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D401/14 ,  A61K45/06 ,  C07D235/16 ,  C07D401/10 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D493/08 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  A61K45/06 ,  C07D235/16 ,  C07D401/10 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D493/08 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20220288030A1

公开(公告)日：2022-09-15

申请号：US17159485

申请日：2021-01-27

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Gediminas J. Brizgys ,  James S. Cassidy ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  Daniel G. Shore ,  Suzanne M. Szewczyk ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang

IPC: A61K31/4184 ,  A61K45/06 ,  C07D405/10 ,  C07D405/14 ,  C07D409/14 ,  C07D413/10 ,  C07D498/04 ,  C07D471/04 ,  C07D493/04 ,  C07D493/10 ,  A61K31/424 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.

公开(公告)号：US20220259234A1

公开(公告)日：2022-08-18

申请号：US17618696

申请日：2020-06-11

Applicant: Gilead Sciences, Inc.

Inventor： Eda Y. Canales ,  Manoj C. Desai ,  Eric Gorman ,  Jiayao Li ,  Roland D. Saito ,  James G. Taylor ,  Nathan E. Wright

IPC: C07F9/6558

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20220235078A1

公开(公告)日：2022-07-28

申请号：US17715366

申请日：2022-04-07

Applicant: Gilead Sciences, Inc.

Inventor： Eda Y. Canales ,  Manoj C. Desai ,  Eric Gorman ,  Jiayao Li ,  Roland D. Saito ,  James G. Taylor ,  Nathan E. Wright

IPC: C07F9/6558 ,  C07D401/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20210214363A1

公开(公告)日：2021-07-15

申请号：US17110734

申请日：2020-12-03

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

公开(公告)号：US20210053990A1

公开(公告)日：2021-02-25

申请号：US16986909

申请日：2020-08-06

Applicant: Gilead Sciences, Inc.

Inventor： Jamie G. Bates ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Brian J. Kirby ,  Yurong Lai ,  Michael L. Mitchell ,  Gregg M. Schwarzwalder ,  James G. Taylor ,  Ting Wang

IPC: C07D519/00

Abstract: The present disclosure relates generally to compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

公开(公告)号：US20200071333A1

公开(公告)日：2020-03-05

申请号：US16539753

申请日：2019-08-13

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US10316017B2

公开(公告)日：2019-06-11

申请号：US15697755

申请日：2017-09-07

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D401/12 ,  C07D453/02 ,  C07D417/14 ,  C07D413/14 ,  C07D413/12 ,  C07D409/14 ,  C07D405/14 ,  C07D401/14 ,  C07F7/08

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.