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公开(公告)号：US20230027019A1
公开(公告)日：2023-01-26
申请号：US17361758
申请日：2021-06-29
发明人： Hang Chu , Ana Z. Gonzalez Buenrostro , Hongyan Guo , Xiaochun Han , Lan Jiang , Jiayao Li , Michael L. Mitchell , Hyung-Jung Pyun , Scott D. Schroeder , Gregg M. Schwarzwalder , Nathan D. Shapiro , Devleena M. Shivakumar , Qiaoyin Wu , Hong Yang , Jennifer R. Zhang
IPC分类号： C07D498/18 , C07D471/18 , A61P31/18
摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US11084832B2
公开(公告)日：2021-08-10
申请号：US16825142
申请日：2020-03-20
发明人： Hang Chu , Ana Z. Gonzalez Buenrostro , Hongyan Guo , Xiaochun Han , Lan Jiang , Jiayao Li , Michael L. Mitchell , Hyung-Jung Pyun , Scott D. Schroeder , Gregg M. Schwarzwalder , Nathan D. Shapiro , Devleena M. Shivakumar , Qiaoyin Wu , Hong Yang , Jennifer R. Zhang
IPC分类号： C07D498/18 , C07D471/18 , A61P31/18
摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20230257389A1
公开(公告)日：2023-08-17
申请号：US18164317
申请日：2023-02-03
发明人： Hang Chu , Ana Z. Gonzalez Buenrostro , Hongyan Guo , Xiaochun Han , Anna E. Hurtley , Lan Jiang , Jiayao Li , David W. Lin , Michael L. Mitchell , Devan Naduthambi , Gregg M. Schwarzwalder , Suzanne M. Szewczyk , Matthew J. Von Bargen , Qiaoyin Wu , Hong Yang , Jennifer R. Zhang
IPC分类号： C07D487/18 , A61P31/18 , C07D487/22 , C07D491/22
CPC分类号： C07D487/18 , A61P31/18 , C07D487/22 , C07D491/22
摘要： The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.
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公开(公告)号：US20210053990A1
公开(公告)日：2021-02-25
申请号：US16986909
申请日：2020-08-06
发明人： Jamie G. Bates , Ana Z. Gonzalez Buenrostro , Hongyan Guo , Xiaochun Han , Brian J. Kirby , Yurong Lai , Michael L. Mitchell , Gregg M. Schwarzwalder , James G. Taylor , Ting Wang
IPC分类号： C07D519/00
摘要： The present disclosure relates generally to compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
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公开(公告)号：US12024528B2
公开(公告)日：2024-07-02
申请号：US18334611
申请日：2023-06-14
发明人： Hang Chu , Ana Z. Gonzalez Buenrostro , Xiaochun Han , Anna E. Hurtley , Lan Jiang , Jiayao Li , Gregg M. Schwarzwalder , Devleena M. Shivakumar , Matthew J. Von Bargen , Qiaoyin Wu , Hong Yang
IPC分类号： C07D498/20 , A61K45/06 , A61P31/18 , C07D471/22 , C07D491/22 , C07D497/22 , C07D498/22 , C07D513/22 , C07D515/22
CPC分类号： C07D498/20 , A61K45/06 , A61P31/18 , C07D471/22 , C07D491/22 , C07D497/22 , C07D498/22 , C07D513/22 , C07D515/22 , C07B2200/05
摘要： The present disclosure relates generally to compounds, of Formula I:
Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.-
公开(公告)号：US20230373950A1
公开(公告)日：2023-11-23
申请号：US18184335
申请日：2023-03-15
发明人： Gayatri Balan , Peter A. Blomgren , Chen Chen , Julian A. Codelli , Zhimin Du , Musong Kim , Dorothée Saddier Axe , Gregg M. Schwarzwalder , Rhiannon Thomas-Tran , Michael T. Tudesco , Chandrasekar Venkataramani , William J. Watkins , Brian M. Weist , Suet C. Yeung , Helen Yu
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07B2200/05
摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
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公开(公告)号：US11697652B2
公开(公告)日：2023-07-11
申请号：US17182559
申请日：2021-02-23
IPC分类号： C07D471/22 , A61P31/18
CPC分类号： C07D471/22 , A61P31/18
摘要： The present disclosure relates generally to certain tetracyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.
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公开(公告)号：US20230203061A1
公开(公告)日：2023-06-29
申请号：US18050650
申请日：2022-10-28
发明人： Hang Chu , Ana Z. Gonzalez Buenrostro , Hongyan Guo , Xiaochun Han , Lan Jiang , Jiayao Li , Michael L. Mitchell , Hyung-Jung Pyun , Scott D. Schroeder , Gregg M. Schwarzwalder , Nathan D. Shapiro , Devleena M. Shivakumar , Qiaoyin Wu , Hong Yang , Jennifer R. Zhang
IPC分类号： C07D498/18 , C07D471/18 , A61P31/18
CPC分类号： C07D498/18 , C07D471/18 , A61P31/18
摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I):
including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.-
公开(公告)号：US20200317689A1
公开(公告)日：2020-10-08
申请号：US16825142
申请日：2020-03-20
发明人： Hang Chu , Ana Z. Gonzalez Buenrostro , Hongyan Guo , Xiaochun Han , Lan Jiang , Jiayao Li , Michael L. Mitchell , Hyung-Jung Pyun , Scott D. Schroeder , Gregg M. Schwarzwalder , Nathan D. Shapiro , Devleena M. Shivakumar , Qiaoyin Wu , Hong Yang , Jennifer R. Zhang
IPC分类号： C07D498/18 , C07D471/18
摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20240300966A1
公开(公告)日：2024-09-12
申请号：US18393778
申请日：2023-12-22
发明人： Hang Chu , Ana Z. Gonzalez Buenrostro , Hongyan Guo , Xiaochun Han , Anna E. Hurtley , Lan Jiang , Jiayao Li , David W. Lin , Michael L. Mitchell , Devan Naduthambi , Gregg M. Schwarzwalder , Suzanne M. Szewczyk , Matthew J. Von Bargen , Qiaoyin Wu , Hong Yang , Jennifer R. Zhang
IPC分类号： C07D487/18 , A61P31/18 , C07D487/22 , C07D491/22
CPC分类号： C07D487/18 , A61P31/18 , C07D487/22 , C07D491/22
摘要： The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.
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