公开(公告)号：US20180250375A1

公开(公告)日：2018-09-06

申请号：US15747671

申请日：2016-07-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Marie-Ange DEMOITIE ,  Marie-Noelle Renelle DONNER ,  Nadia OUAKED

IPC: A61K39/04 ,  A61K45/00 ,  A61K39/12 ,  A61K39/39 ,  C12N15/85 ,  A61K9/00 ,  A61P31/06

CPC classification number: A61K39/04 ,  A61K9/0019 ,  A61K35/761 ,  A61K39/12 ,  A61K39/39 ,  A61K45/05 ,  A61K2039/5256 ,  A61K2039/545 ,  A61P31/06 ,  C07K14/005 ,  C07K14/35 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/10321 ,  C12N2710/10341 ,  C12N2710/10343 ,  C12N2740/16234 ,  C12N2760/18534

Abstract: The present invention relates to methods for inducing an immune response, in particular methods for inducing an immune response against mycobacterial infections or disease comprising (i) at least one administration of a polypeptide Rv1196 related antigen and at least one administration of an adenovirus encoding a Rv1196 related antigen or (ii) at least one administration of a polypeptide Rv0125 related antigen and at least one administration of an adenovirus encoding a Rv0125 related antigen. Associated compositions, adenoviral constructs and polynucleotide sequences are also provided.