公开(公告)号：US20170065715A1

公开(公告)日：2017-03-09

申请号：US15354233

申请日：2016-11-17

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Pierre VANDEPAPELIERE

IPC分类号： A61K39/39 ,  A61K39/102 ,  A61K39/104

CPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/015 ,  A61K39/092 ,  A61K39/102 ,  A61K39/1045 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/57 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/70 ,  C12N2710/10134 ,  C12N2710/16134 ,  C12N2710/16171 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2710/20071 ,  C12N2730/10134 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16234 ,  C12N2760/16271 ,  C12N2760/20034 ,  Y02A50/412

摘要： The present invention provides a human dose of an immunogenic composition comprising an antigen or antigenic preparation, in combination with an adjuvant which adjuvant comprises an immunologically active saponin fraction derived from the bark of Quillaja Saponaria Molina presented in the form of a liposome and a lipopolysaccharide wherein said saponin fraction and said lipopolysaccharide are both present in said human dose at a level of below 30 μg. The present invention further provides an adjuvant composition in a human dose suitable volume comprising between 1 and 30 μg of a lipopolysaccharide and between 1 and 30 μg of an immunologically active saponin fraction presented in the form of a liposome.

摘要翻译： 本发明提供人剂量的免疫原性组合物，其包含与佐剂组合的抗原或抗原制剂，所述佐剂包含衍生自脂质体形式的Quillaja Saponaria Molina的树皮的免疫学活性皂苷级分和脂多糖，其中 所述皂苷部分和所述脂多糖均以所述人类剂量存在，水平低于30μg。 本发明还提供了一种人体剂量合适体积的佐剂组合物，其包含1至30μg脂多糖和1至30μg以脂质体形式存在的免疫学活性皂苷级分。