公开(公告)号：US20240350410A1

公开(公告)日：2024-10-24

申请号：US18683535

申请日：2022-08-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Rushit LODAYA ,  Patrick POHLHAUS ,  Elizabeth ZECCA ,  Jinjin ZHANG ,  Adora PADILLA ,  Erwan BOURLÈS ,  Julie ENERT

IPC: A61K9/127 ,  A61K9/19 ,  A61K31/7105 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: A61K9/1272 ,  A61K9/1271 ,  A61K9/19 ,  A61K31/7105 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26

Abstract: Compositions and methods are provided for stabilization of RNA encapsulated by lipid nanoparticles during lyophilization. Novel lyophilization processes are provided. These techniques may be used to prevent the need for cold chain storage.