公开(公告)号：US20250134824A1

公开(公告)日：2025-05-01

申请号：US18683531

申请日：2022-08-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Rushit LODAYA ,  Patrick POHLHAUS

IPC: A61K9/51 ,  A61K9/19 ,  A61K39/00

Abstract: Compositions and methods are provided for stabilization of RNA encapsulated by lipid nanoparticles during lyophilization. The compositions and methods involve the use of empty lipid nanoparticles to stabilize the lyophilized composition. These techniques may be used to prevent the need for cold chain storage and may also simplify the procedure at the clinic for reconstituting the vaccine to prepare an injectable composition.

公开(公告)号：US20240350410A1

公开(公告)日：2024-10-24

申请号：US18683535

申请日：2022-08-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Rushit LODAYA ,  Patrick POHLHAUS ,  Elizabeth ZECCA ,  Jinjin ZHANG ,  Adora PADILLA ,  Erwan BOURLÈS ,  Julie ENERT

IPC: A61K9/127 ,  A61K9/19 ,  A61K31/7105 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: A61K9/1272 ,  A61K9/1271 ,  A61K9/19 ,  A61K31/7105 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26

Abstract: Compositions and methods are provided for stabilization of RNA encapsulated by lipid nanoparticles during lyophilization. Novel lyophilization processes are provided. These techniques may be used to prevent the need for cold chain storage.

公开(公告)号：US20190298854A1

公开(公告)日：2019-10-03

申请号：US16082674

申请日：2017-03-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA ,  Liquidia Technologies, Inc.

Inventor： Abdelatif A ELOUAHABI ,  Patrick POHLHAUS ,  Laurent Bernard Jean STRODIOT ,  Ashley GALLOWAY ,  Jin Christiane Lee ,  Michele R. STONE

IPC: A61K47/69 ,  A61K9/16 ,  A61K47/64 ,  A61K47/61 ,  A61K39/08 ,  A61K39/102

Abstract: The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to pH such that above a threshold pH level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.