公开(公告)号：US20240350410A1

公开(公告)日：2024-10-24

申请号：US18683535

申请日：2022-08-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Rushit LODAYA ,  Patrick POHLHAUS ,  Elizabeth ZECCA ,  Jinjin ZHANG ,  Adora PADILLA ,  Erwan BOURLÈS ,  Julie ENERT

IPC: A61K9/127 ,  A61K9/19 ,  A61K31/7105 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: A61K9/1272 ,  A61K9/1271 ,  A61K9/19 ,  A61K31/7105 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26

Abstract: Compositions and methods are provided for stabilization of RNA encapsulated by lipid nanoparticles during lyophilization. Novel lyophilization processes are provided. These techniques may be used to prevent the need for cold chain storage.

公开(公告)号：US20250134824A1

公开(公告)日：2025-05-01

申请号：US18683531

申请日：2022-08-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Rushit LODAYA ,  Patrick POHLHAUS

IPC: A61K9/51 ,  A61K9/19 ,  A61K39/00

Abstract: Compositions and methods are provided for stabilization of RNA encapsulated by lipid nanoparticles during lyophilization. The compositions and methods involve the use of empty lipid nanoparticles to stabilize the lyophilized composition. These techniques may be used to prevent the need for cold chain storage and may also simplify the procedure at the clinic for reconstituting the vaccine to prepare an injectable composition.

公开(公告)号：US20220080043A1

公开(公告)日：2022-03-17

申请号：US17423927

申请日：2020-01-29

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Rushit LODAYA ,  Mansoor AMIJI ,  Derek O'HAGAN

IPC: A61K39/39 ,  A61K47/22 ,  A61K47/06

Abstract: Methods of manufacturing squalene and alpha-tocopherol-containing oil-in-water emulsions having small oil droplet particle sizes. Such emulsions being of use as vaccine adjuvants.