公开(公告)号：US20240082379A1

公开(公告)日：2024-03-14

申请号：US18256749

申请日：2021-12-10

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Scilla Buccato ,  Maria Giuliani ,  Alfredo Pezzicoli ,  Marco Spinsanti

IPC: A61K39/095 ,  A61K39/02 ,  A61K39/102 ,  A61K39/104 ,  A61K39/108 ,  A61K39/112 ,  C12N15/70 ,  C12N15/74 ,  C12P1/04

CPC classification number: A61K39/095 ,  A61K39/0258 ,  A61K39/0275 ,  A61K39/099 ,  A61K39/102 ,  A61K39/104 ,  A61K39/1045 ,  A61K39/105 ,  A61K39/107 ,  C12N15/70 ,  C12N15/74 ,  C12P1/04

Abstract: The present invention relates to the field of hyper-blebbing Gram-negative bacterial cells which are genetically modified by modifying the rpsA gene, the rpsA operon and/or 30S ribosomal protein S1 and to native outer membrane vesicles (nOMVs) obtained or obtainable from said genetically modified bacterial cells.