公开(公告)号：US20220235095A1

公开(公告)日：2022-07-28

申请号：US17615254

申请日：2020-06-03

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Carine Berthe Ghislaine DE KESEL ,  Chad Austin FARRENBURG ,  Jeri Kay SANDVICK ,  Jeb Yeatts VANDENBURG

IPC: C07J63/00

Abstract: Saponin extracts containing at least 88% QS-21 main peak and >3% to 10% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.

公开(公告)号：US20230272000A1

公开(公告)日：2023-08-31

申请号：US18098949

申请日：2023-01-19

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ahmad Taimour BAIG ,  Felicie Georgette, Colette DENET ,  Juan Jose DIAZ GARCIA ,  Chad Austin FARRENBURG ,  Lora Lea LAWRENCE ,  Kent Raymond MYERS ,  Jeri Kay SANDVICK ,  Jeb Yeatts VANDENBURG

IPC: C07J63/00 ,  A61K39/12 ,  A61K39/25 ,  A61K39/39 ,  C12N7/00

CPC classification number: C07J63/008 ,  A61K39/12 ,  A61K39/25 ,  A61K39/39 ,  C12N7/00 ,  A61K2039/55555

Abstract: Saponin extracts containing at least 93% QS-21 main peak and 0.25-3% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.

公开(公告)号：US20240024467A1

公开(公告)日：2024-01-25

申请号：US18353169

申请日：2023-07-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ahmad Taimour BAIG ,  Juan Jose DIAZ GARCIA ,  Chad Austin FARRENBURG ,  Kent Raymond MYERS ,  Jeri Kay SANDVICK ,  Jeb Yeatts VANDENBURG

IPC: A61K39/39 ,  A61K36/185

CPC classification number: A61K39/39 ,  A61K36/185 ,  A61K2039/55577

Abstract: Crude aqueous extracts of Quillaja saponaria Molina containing at least the QS-21 main peak and 2018 component, wherein the ratio of 2018 component/QS-21 main peak is 0.075, as measured by UV absorbance at 214 nm, methods for obtaining such extracts and related aspects.

公开(公告)号：US20230355752A1

公开(公告)日：2023-11-09

申请号：US18353172

申请日：2023-07-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ahmad Taimour BAIG ,  Juan Jose DIAZ GARCIA ,  Chad Austin FARRENBURG ,  Kent Raymond MYERS ,  Jeri Kay SANDVICK ,  Jeb Yeatts VANDENBURG

IPC: A61K39/39 ,  A61K36/185

CPC classification number: A61K39/39 ,  A61K36/185 ,  A61K2039/55577

Abstract: Crude aqueous extracts of Quillaja saponaria Molina containing at least the QS-21 main peak and 2018 component, wherein the ratio of 2018 component/QS-21 main peak is ≤0.075, as measured by UV absorbance at 214 nm, methods for obtaining such extracts and related aspects.

公开(公告)号：US20200323980A1

公开(公告)日：2020-10-15

申请号：US16768416

申请日：2018-11-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ahmad Taimour BAIG ,  Juan Jose DIAZ GARCIA ,  Chad Austin FARRENBURG ,  Kent Raymond MYERS ,  Jeri Kay SANDVICK ,  Jeb Yeatts VANDENBURG

IPC: A61K39/39 ,  A61K36/185

Abstract: Crude aqueous extracts of Quillaja saponaria Molina containing at least the QS-21 main peak and 2018 component, wherein the ratio of 2018 component/QS-21 main peak is ≤0.075, as measured by UV absorbance at 214 nm, methods for obtaining such extracts and related aspects.

公开(公告)号：US20200317719A1

公开(公告)日：2020-10-08

申请号：US16768402

申请日：2018-11-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ahmad Taimour BAIG ,  Felicie Georgette, Colette DENET ,  Juan Jose DIAZ GARCIA ,  Chad Austin FARRENBURG ,  Lora Lea LAWRENCE ,  Kent Raymond MYERS ,  Jeri Kay SANDVICK ,  Jeb Yeatts VANDENBURG

IPC: C07J63/00 ,  A61K39/39 ,  A61K39/25 ,  C12N7/00 ,  A61K39/12

Abstract: Saponin extracts containing at least 93% QS-21 main peak and 0.25-3% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.