公开(公告)号：US20170073716A1

公开(公告)日：2017-03-16

申请号：US15309283

申请日：2015-05-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Evita BALDUCCI ,  Francesco BERTI ,  Valdemar Robert JANULCZYK ,  Immaculada MARGARIT Y ROS ,  Chiara TONIOLO

IPC: C12P19/04 ,  A61K39/09 ,  C08B37/00

CPC classification number: C12P19/04 ,  A61K39/092 ,  C07K14/315 ,  C08B37/0003 ,  C08B37/006

Abstract: The invention relates to bacterial mutants, particularly from Streptococcus agalactiae, that secrete capsular polysaccharide and methods of purifying the secreted bacterial capsular polysaccharides from culture medium. The extracted polysaccharides are useful for producing vaccines comprising the polysaccharides alone or conjugated to proteins.

Abstract translation: 本发明涉及分泌荚膜多糖的细菌突变体，特别是无乳链球菌，从培养基中纯化分泌的细菌荚膜多糖的方法。 提取的多糖可用于生产单独的多糖或与蛋白质缀合的疫苗。