公开(公告)号：US20170224803A1

公开(公告)日：2017-08-10

申请号：US15501474

申请日：2015-08-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Francesco BERTI ,  Roberta COZZI ,  Domenico MAIONE ,  Cira Daniela RINAUDO ,  Immaculada MARGARIT Y ROS ,  Guido GRANDI

IPC: A61K39/09 ,  A61K39/095

CPC classification number: A61K39/092 ,  A61K39/09 ,  A61K39/095 ,  A61K47/48 ,  A61K47/646

Abstract: The invention provides a conjugate comprising an antigen and a carrier molecule, wherein the carrier molecule comprises a BP-2a antigen and a spb1 antigen. BP-2a and spb1 are Streptococcus agalactiae antigens. The conjugate may be used in a method for raising an immune response in a mammal, the method comprising administering the conjugate to the mammal. Also provided are pharmaceutical compositions, particularly vaccines, comprising the conjugate.

公开(公告)号：US20230210975A1

公开(公告)日：2023-07-06

申请号：US18008777

申请日：2021-06-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Filippo CARBONI ,  Roberta COZZI ,  Immaculada MARGARIT Y ROS ,  Maria Rosaria ROMANO

IPC: A61K39/09 ,  A61P31/04

CPC classification number: A61K39/092 ,  A61P31/04 ,  A61K2039/6031

Abstract: Methods of inducing an immunogenic response against a bacterial polysaccharide or oligosaccharide, and constructs and compositions for use in such methods.

公开(公告)号：US20230321213A1

公开(公告)日：2023-10-12

申请号：US18025273

申请日：2021-09-09

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Isabel DELANY ,  Giulia GIORDANO ,  Rosanna LEUZZI ,  Immaculada MARGARIT Y ROS

IPC: A61K39/095 ,  A61K39/39 ,  A61P31/04 ,  C12N1/20 ,  C12N1/36

CPC classification number: A61K39/095 ,  A61K39/39 ,  A61P31/04 ,  C12N1/205 ,  C12N1/36 ,  A61K2039/521

Abstract: The present invention relates to the field of neisserial vaccine compositions (particularly gonococcal vaccine compositions) and the use of such compositions in medicine. More particularly, the present invention relates to genetically modified gonococci of strain FA1090 and outer membrane vesicles obtained therefrom. The invention also provides a process for preparing the genetically modified gonococci of the invention as well as immunogenic compositions and vaccines comprising the outer membrane vesicles of the invention.

公开(公告)号：US20170073716A1

公开(公告)日：2017-03-16

申请号：US15309283

申请日：2015-05-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Evita BALDUCCI ,  Francesco BERTI ,  Valdemar Robert JANULCZYK ,  Immaculada MARGARIT Y ROS ,  Chiara TONIOLO

IPC: C12P19/04 ,  A61K39/09 ,  C08B37/00

CPC classification number: C12P19/04 ,  A61K39/092 ,  C07K14/315 ,  C08B37/0003 ,  C08B37/006

Abstract: The invention relates to bacterial mutants, particularly from Streptococcus agalactiae, that secrete capsular polysaccharide and methods of purifying the secreted bacterial capsular polysaccharides from culture medium. The extracted polysaccharides are useful for producing vaccines comprising the polysaccharides alone or conjugated to proteins.

Abstract translation: 本发明涉及分泌荚膜多糖的细菌突变体，特别是无乳链球菌，从培养基中纯化分泌的细菌荚膜多糖的方法。 提取的多糖可用于生产单独的多糖或与蛋白质缀合的疫苗。