公开(公告)号：US20170224803A1

公开(公告)日：2017-08-10

申请号：US15501474

申请日：2015-08-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Francesco BERTI ,  Roberta COZZI ,  Domenico MAIONE ,  Cira Daniela RINAUDO ,  Immaculada MARGARIT Y ROS ,  Guido GRANDI

IPC: A61K39/09 ,  A61K39/095

CPC classification number: A61K39/092 ,  A61K39/09 ,  A61K39/095 ,  A61K47/48 ,  A61K47/646

Abstract: The invention provides a conjugate comprising an antigen and a carrier molecule, wherein the carrier molecule comprises a BP-2a antigen and a spb1 antigen. BP-2a and spb1 are Streptococcus agalactiae antigens. The conjugate may be used in a method for raising an immune response in a mammal, the method comprising administering the conjugate to the mammal. Also provided are pharmaceutical compositions, particularly vaccines, comprising the conjugate.

公开(公告)号：US20180036402A1

公开(公告)日：2018-02-08

申请号：US15705873

申请日：2017-09-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Francesco BERTI ,  Mario CONTORNI ,  Paolo COSTANTINO ,  Oretta FINCO ,  Guido GRANDI ,  Domenico MAIONE ,  John TELFORD

IPC: A61K39/385 ,  A61K39/09 ,  A61K39/00

CPC classification number: A61K39/385 ,  A61K39/092 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/627

Abstract: A method of immunization against Group B Streptococcus infection, using an immunogenic composition conjugates of GBS capsular saccharide conjugated to carrier proteins.