公开(公告)号：US10150979B2

公开(公告)日：2018-12-11

申请号：US15309283

申请日：2015-05-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Evita Balducci ,  Francesco Berti ,  Valdemar Robert Janulczyk ,  Immaculada Margarit Y Ros ,  Chiara Toniolo

IPC: C12P19/04 ,  A61K39/09 ,  C07K14/315 ,  C08B37/00

Abstract: The invention relates to bacterial mutants, particularly from Streptococcus agalactiae, that secrete capsular polysaccharide and methods of purifying the secreted bacterial capsular polysaccharides from culture medium. The extracted polysaccharides are useful for producing vaccines comprising the polysaccharides alone or conjugated to proteins.