公开(公告)号：US10245310B2

公开(公告)日：2019-04-02

申请号：US15501474

申请日：2015-08-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Francesco Berti ,  Roberta Cozzi ,  Domenico Maione ,  Cira Daniela Rinaudo ,  Immaculada Margarit Y Ros ,  Guido Grandi

IPC: A61K39/09 ,  A61K39/095 ,  A61K47/48

Abstract: The invention provides a conjugate comprising an antigen and a carrier molecule, wherein the carrier molecule comprises a BP-2a antigen and a spb1 antigen. BP-2a and spb1 are Streptococcus agalactiae antigens. The conjugate may be used in a method for raising an immune response in a mammal, the method comprising administering the conjugate to the mammal. Also provided are pharmaceutical compositions, particularly vaccines, comprising the conjugate.

公开(公告)号：US20180104324A1

公开(公告)日：2018-04-19

申请号：US15819312

申请日：2017-11-21

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Guido Grandi ,  Immaculada Margarit Y Ros ,  Domenico Maione

IPC: A61K39/09 ,  A61K39/13 ,  A61K9/00 ,  A61K39/00 ,  A61K39/05 ,  A61K39/08 ,  A61K39/02 ,  C12N7/00 ,  A61K39/12

CPC classification number: A61K39/092 ,  A61K9/0019 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/08 ,  A61K39/099 ,  A61K39/12 ,  A61K39/13 ,  A61K47/646 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/32334 ,  C12N2770/32634 ,  Y02A50/466

Abstract: Methods for raising an immune response in a mammal, by administration of an immunogenic composition comprising capsular saccharides from Streptococcus agalactiae (GBS) serotypes conjugated to carrier proteins.

公开(公告)号：US09764027B2

公开(公告)日：2017-09-19

申请号：US14424839

申请日：2013-09-18

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Guido Grandi ,  Immaculada Margarit Y Ros ,  Emiliano Chiarot

IPC: A61K39/39 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K39/092 ,  A61K39/095 ,  A61K2039/55555

Abstract: The present invention provides an outer membrane vesicle (OMV) from a Gram-negative bacterium, comprising at least one heterologous protein that is free in the lumen of the OMV, wherein the OMV is capable of eliciting an immune response to the heterologous protein when administered to a mammal. The invention also provides methods for preparing the OMVs of the invention, pharmaceutical compositions comprising the OMVs of the invention, especially immunogenic compositions and vaccines, and methods of generating an antibody immune response in a mammal using OMVs.

公开(公告)号：US10150979B2

公开(公告)日：2018-12-11

申请号：US15309283

申请日：2015-05-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Evita Balducci ,  Francesco Berti ,  Valdemar Robert Janulczyk ,  Immaculada Margarit Y Ros ,  Chiara Toniolo

IPC: C12P19/04 ,  A61K39/09 ,  C07K14/315 ,  C08B37/00

Abstract: The invention relates to bacterial mutants, particularly from Streptococcus agalactiae, that secrete capsular polysaccharide and methods of purifying the secreted bacterial capsular polysaccharides from culture medium. The extracted polysaccharides are useful for producing vaccines comprising the polysaccharides alone or conjugated to proteins.

公开(公告)号：US09855325B2

公开(公告)日：2018-01-02

申请号：US14424370

申请日：2013-10-03

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Guido Grandi ,  Immaculada Margarit Y Ros ,  Domenico Maione

IPC: A61K39/09 ,  A61K39/00 ,  A61K39/05 ,  A61K39/08 ,  A61K39/02 ,  A61K39/13 ,  A61K39/12 ,  C12N7/00 ,  A61K9/00 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K9/0019 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/08 ,  A61K39/099 ,  A61K39/12 ,  A61K39/13 ,  A61K47/646 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/32334 ,  C12N2770/32634 ,  Y02A50/466

Abstract: The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype Ia conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype Ib conjugated to a carrier protein; c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein; d) a conjugate that is a capsular saccharide from GBS serotype II conjugated to a carrier protein; and e) a conjugate that is a capsular saccharide from GBS serotype V conjugated to a carrier protein.

公开(公告)号：US10286055B2

公开(公告)日：2019-05-14

申请号：US15819312

申请日：2017-11-21

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Guido Grandi ,  Immaculada Margarit Y Ros ,  Domenico Maione

IPC: A61K9/00 ,  C12N7/00 ,  A61K39/09 ,  A61K39/00 ,  A61K39/05 ,  A61K39/08 ,  A61K39/02 ,  A61K39/13 ,  A61K39/12 ,  A61K47/64

Abstract: Methods for raising an immune response in a mammal, by administration of an immunogenic composition comprising capsular saccharides from Streptococcus agalactiae (GBS) serotypes conjugated to carrier proteins.

公开(公告)号：US09855324B2

公开(公告)日：2018-01-02

申请号：US14424362

申请日：2013-10-03

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Mario Contorni ,  Guido Grandi ,  Domenico Maione ,  Immaculada Margarit Y Ros

IPC: A61K39/09 ,  A61K39/00 ,  A61K39/05 ,  A61K39/08 ,  A61K39/02 ,  A61K39/13 ,  A61K39/12 ,  C12N7/00 ,  A61K9/00 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K9/0019 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/08 ,  A61K39/099 ,  A61K39/12 ,  A61K39/13 ,  A61K47/646 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/32334 ,  C12N2770/32634 ,  Y02A50/466

Abstract: The invention provides an immunogenic composition comprising one or more GBS conjugates and one or more antigens selected from: a) cellular or acellular pertussis antigen, b) a tetanus toxoid, c) a diphtheria toxoid and d) an inactivated polio virus antigen, wherein each GBS conjugate is a group B streptococcus capsular saccharide conjugated to a carrier protein. The invention also provides a method for raising an immune response in a patient, comprising the step of administering to the patient a composition of the invention.