公开(公告)号：US20230234992A1

公开(公告)日：2023-07-27

申请号：US18007931

申请日：2021-06-04

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco BIANCUCCI ,  Joel David KARPIAK ,  Jason Paul LALIBERTE ,  Anna Ulrika LOWEGARD ,  Enrico MALITO ,  Newton Muchugu WAHOME

IPC: C07K14/165 ,  C12N15/11 ,  A61K39/215 ,  A61P31/14

CPC classification number: C07K14/165 ,  C12N15/11 ,  A61K39/215 ,  A61P31/14 ,  A61K2039/575

Abstract: Betacoronavirus Spike proteins, or fragments thereof, including substitution mutations designed to increase stability, decrease the risk of antibody dependent enhancement, or both; and that are useful in, for example, immunogenic compositions.