公开(公告)号：US20250101067A1

公开(公告)日：2025-03-27

申请号：US18832219

申请日：2023-01-19

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco BIANCUCCI ,  Newton Muchugu WAHOME

IPC: C07K14/005 ,  A61K39/00 ,  C07K14/39 ,  C12N9/88

Abstract: Modified HCMV gB proteins in a pre-fusion conformation, compositions comprising such proteins, and uses thereof.

公开(公告)号：US20230234992A1

公开(公告)日：2023-07-27

申请号：US18007931

申请日：2021-06-04

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco BIANCUCCI ,  Joel David KARPIAK ,  Jason Paul LALIBERTE ,  Anna Ulrika LOWEGARD ,  Enrico MALITO ,  Newton Muchugu WAHOME

IPC: C07K14/165 ,  C12N15/11 ,  A61K39/215 ,  A61P31/14

CPC classification number: C07K14/165 ,  C12N15/11 ,  A61K39/215 ,  A61P31/14 ,  A61K2039/575

Abstract: Betacoronavirus Spike proteins, or fragments thereof, including substitution mutations designed to increase stability, decrease the risk of antibody dependent enhancement, or both; and that are useful in, for example, immunogenic compositions.

公开(公告)号：US20230201334A1

公开(公告)日：2023-06-29

申请号：US17628351

申请日：2020-07-22

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco BIANCUCCI ,  Sumana CHANDRAMOULI ,  Newton Muchugu WAHOME

IPC: A61K39/245 ,  C07K14/005

CPC classification number: A61K39/245 ,  C07K14/005

Abstract: Modified HCMV gB proteins in a non-post-fusogenic conformation, compositions comprising such proteins, and uses thereof.

公开(公告)号：US20230174626A1

公开(公告)日：2023-06-08

申请号：US17913264

申请日：2021-03-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco BIANCUCCI ,  Sumana CHANDRAMOULI ,  Kate LUISI

IPC: C07K16/08 ,  G01N33/569

CPC classification number: C07K16/088 ,  G01N33/56994 ,  C07K2317/24 ,  C07K2317/565

Abstract: Monoclonal antibodies and antigen binding fragments that specifically bind to the Human Cytomegalovirus (HCMV) pentamer protein complex (gH/gL/UL128/UL130/UL131A) or other gH-containing complexes, and uses thereof.