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公开(公告)号：US20170008933A1
公开(公告)日：2017-01-12
申请号：US15120674
申请日：2015-02-27
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI , Maria SCARSELLI
IPC: C07K14/22 , A61K47/48 , A61K39/095
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/523 , A61K2039/55511 , A61K2039/70
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
Abstract translation: 改良的脑膜炎球菌fHbp多肽具有增加的稳定性。
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公开(公告)号：US20240218026A1
公开(公告)日：2024-07-04
申请号：US18440212
申请日：2024-02-13
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI , Maria SCARSELLI
IPC: C07K14/22 , A61K39/095 , A61K39/00
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/523 , A61K2039/55511 , A61K2039/70
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号：US20210277067A1
公开(公告)日：2021-09-09
申请号：US17223207
申请日：2021-04-06
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Enrico MALITO , Matthew James BOTTOMLEY , Andrea CARFI , Sumana CHANDRAMOULI , Kate LUISI
IPC: C07K14/045 , A61K39/245 , A61K38/00
Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
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Patent Agency Ranking
公开(公告)号：US20230234992A1
公开(公告)日：2023-07-27
申请号：US18007931
申请日：2021-06-04
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Marco BIANCUCCI , Joel David KARPIAK , Jason Paul LALIBERTE , Anna Ulrika LOWEGARD , Enrico MALITO , Newton Muchugu WAHOME
IPC: C07K14/165 , C12N15/11 , A61K39/215 , A61P31/14
CPC classification number: C07K14/165 , C12N15/11 , A61K39/215 , A61P31/14 , A61K2039/575
Abstract: Betacoronavirus Spike proteins, or fragments thereof, including substitution mutations designed to increase stability, decrease the risk of antibody dependent enhancement, or both; and that are useful in, for example, immunogenic compositions.
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公开(公告)号：US20210253647A1
公开(公告)日：2021-08-19
申请号：US17245681
申请日：2021-04-30
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI , Maria Scarselli
IPC: C07K14/22 , A61K39/095
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号：US20250009874A1
公开(公告)日：2025-01-09
申请号：US18650745
申请日：2024-04-30
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Enrico MALITO , Sumana CHANDRAMOULI , Andrea CARFI , Matthew BOTTOMLEY
IPC: A61K39/245 , A61K47/64 , C07K14/005
Abstract: Described are mutant, human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
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公开(公告)号：US20240383949A1
公开(公告)日：2024-11-21
申请号：US18435026
申请日：2024-02-07
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Enrico MALITO , Matthew James BOTTOMLEY , Andrea CARFI , Sumana CHANDRAMOULI , Kate LUISI
IPC: C07K14/045 , A61K38/00 , A61K39/245
Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
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公开(公告)号：US20190315812A1
公开(公告)日：2019-10-17
申请号：US16458365
申请日：2019-07-01
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI
IPC: C07K14/22 , A61K39/095
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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