公开(公告)号：US20240293535A1

公开(公告)日：2024-09-05

申请号：US18262033

申请日：2022-01-18

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Johann MOLS ,  Marie TOUSSAINT

IPC: A61K39/245 ,  A61P31/22 ,  C07K14/005

CPC classification number: A61K39/245 ,  A61P31/22 ,  C07K14/005 ,  C12N2710/16622 ,  C12N2710/16634

Abstract: The present invention relates to a HSV2 Fc receptor or immunogenic fragment or variant thereof for use in generating a cross reactive immune response against HSV1 in a subject. Also provided is a HSV1 Fc receptor or immunogenic fragment or variant thereof for use in generating a cross reactive immune response against HSV2 when administered to a subject.

公开(公告)号：US20240091345A1

公开(公告)日：2024-03-21

申请号：US18262073

申请日：2022-01-18

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Johann MOLS ,  Marie TOUSSAINT

IPC: A61K39/245 ,  A61P31/22

CPC classification number: A61K39/245 ,  A61P31/22 ,  A61K2039/53

Abstract: The present invention relates to a nucleic acid encoding a HSV2 Fc receptor or immunogenic fragment or variant thereof for use in generating a cross reactive immune response against HSV1 in a subject. Also provided is a nucleic acid encoding a HSV1 Fc receptor or immunogenic fragment or variant thereof for use in generating a cross reactive immune response against HSV2 when administered to a subject.

公开(公告)号：US20220273789A1

公开(公告)日：2022-09-01

申请号：US17627998

申请日：2020-07-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Normand BLAIS ,  Cindy CASTADO ,  Johann MOLS ,  Lionel SACCONNAY ,  Marie TOUSSAINT ,  Newton Muchugu WAHOME ,  Giulietta MARUGGI

IPC: A61K39/245 ,  C07K14/005 ,  A61P31/22 ,  A61P37/04

Abstract: The present invention relates to viral Fc receptor or immunogenic fragments thereof for treating a viral infection in a subject and, in particular, a herpes vims infection. The present invention also relates to a heterodimer comprising or consisting of an Fc receptor from a HSV vims or an immunogenic fragment thereof and a binding partner from said HSV vims or a fragment thereof, for use in therapy.