公开(公告)号：US20220273789A1

公开(公告)日：2022-09-01

申请号：US17627998

申请日：2020-07-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Normand BLAIS ,  Cindy CASTADO ,  Johann MOLS ,  Lionel SACCONNAY ,  Marie TOUSSAINT ,  Newton Muchugu WAHOME ,  Giulietta MARUGGI

IPC: A61K39/245 ,  C07K14/005 ,  A61P31/22 ,  A61P37/04

Abstract: The present invention relates to viral Fc receptor or immunogenic fragments thereof for treating a viral infection in a subject and, in particular, a herpes vims infection. The present invention also relates to a heterodimer comprising or consisting of an Fc receptor from a HSV vims or an immunogenic fragment thereof and a binding partner from said HSV vims or a fragment thereof, for use in therapy.

公开(公告)号：US20220062409A1

公开(公告)日：2022-03-03

申请号：US17413203

申请日：2019-12-13

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefania CAPONE ,  Nicolas Frederic DELAHAYE ,  Giulietta MARUGGI ,  Haifeng SONG

IPC: A61K39/245 ,  A61K39/21 ,  A61K39/205 ,  A61P31/14 ,  A61P31/18 ,  A61P31/22

Abstract: Simian adenoviral vectors and RNA molecules, each encoding an immunogen of interest, can be sequentially administered to provide potent and long-lasting immunity.

公开(公告)号：US20250099576A1

公开(公告)日：2025-03-27

申请号：US18964896

申请日：2024-12-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Giulietta MARUGGI ,  Kambiz MOUSAVI ,  Newton WAHOME ,  Jason William WESTERBECK ,  Magdalena Aleksandra ZWIERZYNA ,  Yoo-Ah KIM ,  Amirali YAZDI ,  Yamina BENNASSER

IPC: A61K39/215 ,  A61K9/51 ,  A61K39/00 ,  C07K14/005 ,  C07K16/10 ,  C12P19/34

Abstract: Provided herein are 3′ and 5′ UTRs that provide an amount, duration, or both of protein expression from a recombinant RNA. Compositions of matter, methods, or uses of said 3′ and 5′ UTRs are provided. Provided herein are RNA segments that encode a SARS-CoV-2 omicron spike protein, which provide for omicron-strain-specific immunogenic compositions. Compositions of matter, methods, or uses of said RNA segments that encode a SARS-CoV-2 omicron spike protein are provided.

公开(公告)号：US20240189417A1

公开(公告)日：2024-06-13

申请号：US18425426

申请日：2024-01-29

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Giulietta MARUGGI ,  Qiongman KONG ,  Varnika ROY ,  Dong YU ,  Meng ZHANG

IPC: A61K39/215 ,  A61K39/00 ,  A61K39/02 ,  A61P31/14 ,  A61P37/04 ,  C12P19/34

CPC classification number: A61K39/215 ,  A61K39/0002 ,  A61K39/0011 ,  A61K39/0013 ,  A61K39/02 ,  A61P31/14 ,  A61P37/04 ,  C12P19/34 ,  A61K2039/53

Abstract: Provided herein are RNA that: are collectively self-amplifying in an intracellular environment, comprise N1-methyl-pseudouridines and uridines, and have a mole percentage or mole proportion of the N1-methylpseudouridines to the total of the uridines and the Ni-methylpseudouridines or a mole ration of the N1-methylpseudouridines to the uridines.

公开(公告)号：US20240301006A1

公开(公告)日：2024-09-12

申请号：US18269120

申请日：2021-12-21

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Giulietta MARUGGI ,  Jason William WESTERBECK ,  Dong YU

IPC: C07K14/005 ,  A61K9/127 ,  A61K39/00 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K9/127 ,  C12N15/86 ,  A61K39/00 ,  A61K2039/55555 ,  A61K2039/572 ,  A61K2039/575 ,  C12N2710/24122 ,  C12N2710/24133 ,  C12N2760/14122 ,  C12N2760/14133 ,  C12N2760/16122 ,  C12N2760/16133 ,  C12N2770/36143

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an interferon effector.

公开(公告)号：US20230364219A1

公开(公告)日：2023-11-16

申请号：US17918676

申请日：2021-04-16

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Dong YU ,  Giulietta MARUGGI ,  Jason W. WESTERBECK ,  Jeffrey B. ULMER ,  Jason P. LALIBERTE ,  Kate LUISI ,  Lin QU

IPC: A61K39/215 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61P37/04 ,  A61K2039/55566

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an antigen, in particular a Coronavirus antigen.