公开(公告)号：US12161707B2

公开(公告)日：2024-12-10

申请号：US15693663

申请日：2017-09-01

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Mariagrazia Pizza ,  Marzia Monica Giuliani ,  Elisabetta Monaci

IPC: A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/64 ,  C07K14/22 ,  C07K16/12 ,  A61K39/00

Abstract: Methods and compositions for immunizing a human subject against Neisseria gonorrhoeae.

公开(公告)号：US20180214531A1

公开(公告)日：2018-08-02

申请号：US15319665

申请日：2015-07-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Alessia Biolchi ,  Brunella Brunelli ,  Marzia Monica Giuliani ,  Vega Masignani

IPC: A61K39/095 ,  A61K39/385 ,  C07K14/22 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/70 ,  C07K14/22 ,  C07K2319/00

Abstract: Meningococcal vaccines can be improved by including multiple alleles or variants of fHbp, in order to provide broader coverage of the diversity which is known for this protein, and/or by reducing the quantity of an OMV component in each dose.

公开(公告)号：US09610342B2

公开(公告)日：2017-04-04

申请号：US15015004

申请日：2016-02-03

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Marzia Monica Giuliani ,  Mariagrazia Pizza ,  Rino Rappuoli

IPC: A61K39/095 ,  C07K14/00 ,  C07K14/22 ,  A61K38/16 ,  A61K39/39 ,  A61K39/02 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K38/164 ,  A61K39/00 ,  A61K39/02 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/70 ,  C07K14/22

Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.

公开(公告)号：US10376573B2

公开(公告)日：2019-08-13

申请号：US14407987

申请日：2013-06-14

Applicant: GlaxoSmithKline Biologicals SA ,  Institut Pasteur

Inventor： Mariagrazia Pizza ,  Peter Dull ,  Marzia Monica Giuliani ,  Muhamed-Kheir Taha ,  Eva Hong ,  Ala-Eddine Deghmane

IPC: A61K39/095 ,  A61K39/39 ,  A61K39/00

Abstract: A method for immunizing a subject against serogroup X meningococcus by administering a vaccine comprising one, two or all three of: (i) a meningococcal fHbp antigen; (ii) a meningococcal NHBA antigen; and/or (iii) a meningococcal NadA antigen. The vaccine may also include meningococcal outer membrane vesicles.

公开(公告)号：US09364528B1

公开(公告)日：2016-06-14

申请号：US15015041

申请日：2016-02-03

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Marzia Monica Giuliani ,  Mariagrazia Pizza ,  Rino Rappuoli

IPC: A61K39/095 ,  A61K39/02 ,  A61K39/00 ,  A61K39/39

CPC classification number: A61K39/095 ,  A61K38/164 ,  A61K39/00 ,  A61K39/02 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/70 ,  C07K14/22

Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.

Abstract translation: 组合物包含来自奈瑟氏球菌细菌的第一生物分子和来自奈顿球菌细菌的第二生物分子。 术语“生物分子”包括蛋白质和核酸。 优选的奈瑟氏菌属是脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌。

公开(公告)号：US11707513B2

公开(公告)日：2023-07-25

申请号：US15319665

申请日：2015-07-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Alessia Biolchi ,  Brunella Brunelli ,  Marzia Monica Giuliani ,  Vega Masignani

IPC: A61K39/095 ,  C07K14/22 ,  A61K39/00 ,  A61K39/385

CPC classification number: A61K39/095 ,  A61K39/385 ,  C07K14/22 ,  A61K39/00 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/70 ,  C07K2319/00

Abstract: Meningococcal vaccines can be improved by including multiple alleles or variants of fHbp, in order to provide broader coverage of the diversity which is known for this protein, and/or by reducing the quantity of an OMV component in each dose.