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公开(公告)号：US11939357B2
公开(公告)日：2024-03-26
申请号：US17346362
申请日：2021-06-14
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew Bottomley , Vega Masignani
IPC: C07K14/22 , A61K39/00 , A61K39/095
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/575 , C07K2319/33
Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.
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公开(公告)号：US20180214531A1
公开(公告)日：2018-08-02
申请号：US15319665
申请日：2015-07-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Alessia Biolchi , Brunella Brunelli , Marzia Monica Giuliani , Vega Masignani
IPC: A61K39/095 , A61K39/385 , C07K14/22 , A61K39/00
CPC classification number: A61K39/095 , A61K39/00 , A61K39/385 , A61K2039/545 , A61K2039/55505 , A61K2039/70 , C07K14/22 , C07K2319/00
Abstract: Meningococcal vaccines can be improved by including multiple alleles or variants of fHbp, in order to provide broader coverage of the diversity which is known for this protein, and/or by reducing the quantity of an OMV component in each dose.
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公开(公告)号：US10035826B2
公开(公告)日：2018-07-31
申请号：US15150204
申请日：2016-05-09
Inventor： Vega Masignani , Danilo Gomes Moriel , Francesco Berlanda Scorza , Nathalie Norais , Maria Rita Fontana , Mariagrazia Pizza , Laura Serino , Herve Tettelin
IPC: A61K39/02 , C07K14/245 , C07K16/12 , A61K39/108 , A61K39/00
CPC classification number: C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/505 , A61K2039/523 , C07K16/1232
Abstract: Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunizing against MNEC infections.
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公开(公告)号：US09764020B2
公开(公告)日：2017-09-19
申请号：US15050107
申请日：2016-02-22
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC: A61K39/085 , C07K14/31 , A61K39/00
CPC classification number: A61K39/085 , A61K2039/70 , C07K14/31
Abstract: The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US20170226161A1
公开(公告)日：2017-08-10
申请号：US15319651
申请日：2015-07-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Matthew Bottomley , Vega Masignani
IPC: C07K14/22 , A61K39/095
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/575 , C07K2319/33
Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHbp which can be modified to enhance their properties.
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Patent Agency Ranking
公开(公告)号：US09249198B2
公开(公告)日：2016-02-02
申请号：US14450082
申请日：2014-08-01
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC classification number: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US11707513B2
公开(公告)日：2023-07-25
申请号：US15319665
申请日：2015-07-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Alessia Biolchi , Brunella Brunelli , Marzia Monica Giuliani , Vega Masignani
IPC: A61K39/095 , C07K14/22 , A61K39/00 , A61K39/385
CPC classification number: A61K39/095 , A61K39/385 , C07K14/22 , A61K39/00 , A61K2039/545 , A61K2039/55505 , A61K2039/70 , C07K2319/00
Abstract: Meningococcal vaccines can be improved by including multiple alleles or variants of fHbp, in order to provide broader coverage of the diversity which is known for this protein, and/or by reducing the quantity of an OMV component in each dose.
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公开(公告)号：US10226524B2
公开(公告)日：2019-03-12
申请号：US15679910
申请日：2017-08-17
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC: A61K39/085 , C07K14/31 , A61K39/00
Abstract: The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US09266929B2
公开(公告)日：2016-02-23
申请号：US14450075
申请日：2014-08-01
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC: C12P21/00 , C12N15/00 , C12N15/09 , C07K14/22 , A61K39/095
CPC classification number: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US11066450B2
公开(公告)日：2021-07-20
申请号：US15319651
申请日：2015-07-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Matthew Bottomley , Vega Masignani
IPC: C07K14/22 , A61K39/095 , A61K39/00
Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHbp which can be modified to enhance their properties.
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