公开(公告)号：US20240293524A1

公开(公告)日：2024-09-05

申请号：US18620109

申请日：2024-03-28

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Renzo ALFINI ,  Roberta Di Benedetto ,  Francesca Micoli ,  Allan James Saul

IPC: A61K39/095 ,  A61K35/74 ,  A61K39/00 ,  A61K39/108 ,  A61K47/69

CPC classification number: A61K39/095 ,  A61K35/74 ,  A61K39/0258 ,  A61K47/6911 ,  A61K2039/6018 ,  A61K2039/6087 ,  A61K2039/627

Abstract: The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.

公开(公告)号：US20220008529A1

公开(公告)日：2022-01-13

申请号：US16636560

申请日：2018-08-08

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Renzo ALFINI ,  Roberta DI BENEDETTO ,  Francesca MICOLI ,  Allan James SAUL

IPC: A61K39/095 ,  A61K35/74 ,  A61K39/108 ,  A61K47/69

Abstract: The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.