公开(公告)号：US20240000958A1

公开(公告)日：2024-01-04

申请号：US18252783

申请日：2021-11-12

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Francesca Micoli ,  Roberta Di Benedetto ,  Allan Saul

IPC: A61K47/64 ,  A61K39/09 ,  A61P31/04

CPC classification number: A61K47/646 ,  A61K39/092 ,  A61P31/04 ,  A61K2039/6037

Abstract: The present invention is directed to a polysaccharide conjugate comprising or consisting of a one or more polysaccharide conjugated to a carrier polypeptide, wherein the carrier polypeptide is selected from the group consisting of (a) a Streptococcus pyogenes SpyAD (Spy0269, GAS40), a Streptococcus pyogenes SpyCEP (Spy0416, GAS57), or Streptococcus pyogenes SLO (Spy0167, GAS25); (b) CRM197; or (c) a variant, fragment and/or fusion of (a) or (b), improved conjugation methods, and uses of said conjugates for preventing or treating disease.

公开(公告)号：US12005109B2

公开(公告)日：2024-06-11

申请号：US16636560

申请日：2018-08-08

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Renzo Alfini ,  Roberta Di Benedetto ,  Francesca Micoli ,  Allan James Saul

IPC: A61K39/095 ,  A61K35/74 ,  A61K39/00 ,  A61K39/108 ,  A61K47/69

CPC classification number: A61K39/095 ,  A61K35/74 ,  A61K39/0258 ,  A61K47/6911 ,  A61K2039/6018 ,  A61K2039/6087 ,  A61K2039/627

Abstract: The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.

公开(公告)号：US20240293524A1

公开(公告)日：2024-09-05

申请号：US18620109

申请日：2024-03-28

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Renzo ALFINI ,  Roberta Di Benedetto ,  Francesca Micoli ,  Allan James Saul

IPC: A61K39/095 ,  A61K35/74 ,  A61K39/00 ,  A61K39/108 ,  A61K47/69

CPC classification number: A61K39/095 ,  A61K35/74 ,  A61K39/0258 ,  A61K47/6911 ,  A61K2039/6018 ,  A61K2039/6087 ,  A61K2039/627

Abstract: The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.