公开(公告)号：US20140235840A1

公开(公告)日：2014-08-21

申请号：US14348432

申请日：2012-09-28

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin ,  Julien Boutet ,  Filippo Bonaccorsi ,  Gyula Dekany

IPC: C07H1/00 ,  C07H3/02 ,  C07H9/04

CPC classification number: C07H1/00 ,  C07D493/04 ,  C07H3/02 ,  C07H3/08 ,  C07H9/02 ,  C07H9/04 ,  C07H11/00

Abstract: A process for converting D-glucose into L-fucose, where a first aspect of the disclosure relates to a method of making a compound of formula (1) wherein R is independently H, alkyl or phenyl or, preferably, wherein the two germinal R groups together with the carbon atom to which they are attached form a C3-s cycloalkylidene group, including the step of treating a compound of formula (2) wherein R is defined above and R1 is a sulphonate leaving group, with a reducing complex metal hydride and, preferably, a base to form the compound of formula (1); a compound of formula (13).

Abstract translation: 将D-葡萄糖转化为L-岩藻糖的方法，其中本公开的第一方面涉及制备式（1）化合物的方法，其中R独立地为H，烷基或苯基，或优选地，其中两个生发R 基团与它们所连接的碳原子一起形成C 3 -S亚环烷基，包括用还原性络合物金属氢化物处理式（2）化合物，其中R定义如上，R1是磺酸根离去基团的步骤 和优选地形成式（1）化合物的碱; 式（13）的化合物。