公开(公告)号：US20140303363A1

公开(公告)日：2014-10-09

申请号：US14363675

申请日：2012-12-07

Applicant: Glycom A/S

Inventor： Markus Hederos ,  Christian Risinger ,  Julien Boutet ,  Gyula Dekany

IPC: C07H15/18 ,  C07H15/12 ,  C07H5/06

CPC classification number: C07H15/12 ,  C07H1/00 ,  C07H5/06 ,  C07H15/18 ,  Y02P20/55

Abstract: The invention relates to providing isolactosamine (Galβ1-3GlcNH2, formula 1) and salts thereof in the form of either anomer or mixture thereof, as well as hydrates or solvates of the free base and salts thereof. The synthesis of isolactosamine and its use in the synthesis of lacto-N-biose containing oligosaccharides are also disclosed.

Abstract translation: 本发明涉及提供异构体或其混合物形式的异乳糖胺（Gal＆bgr; 1-3GlcNH 2，式1）及其盐，以及游离碱及其盐的水合物或溶剂合物。 还公开了异乳糖胺的合成及其在合成含有乳-N-降糖的低聚糖中的用途。

公开(公告)号：US20140235840A1

公开(公告)日：2014-08-21

申请号：US14348432

申请日：2012-09-28

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin ,  Julien Boutet ,  Filippo Bonaccorsi ,  Gyula Dekany

IPC: C07H1/00 ,  C07H3/02 ,  C07H9/04

CPC classification number: C07H1/00 ,  C07D493/04 ,  C07H3/02 ,  C07H3/08 ,  C07H9/02 ,  C07H9/04 ,  C07H11/00

Abstract: A process for converting D-glucose into L-fucose, where a first aspect of the disclosure relates to a method of making a compound of formula (1) wherein R is independently H, alkyl or phenyl or, preferably, wherein the two germinal R groups together with the carbon atom to which they are attached form a C3-s cycloalkylidene group, including the step of treating a compound of formula (2) wherein R is defined above and R1 is a sulphonate leaving group, with a reducing complex metal hydride and, preferably, a base to form the compound of formula (1); a compound of formula (13).

Abstract translation: 将D-葡萄糖转化为L-岩藻糖的方法，其中本公开的第一方面涉及制备式（1）化合物的方法，其中R独立地为H，烷基或苯基，或优选地，其中两个生发R 基团与它们所连接的碳原子一起形成C 3 -S亚环烷基，包括用还原性络合物金属氢化物处理式（2）化合物，其中R定义如上，R1是磺酸根离去基团的步骤 和优选地形成式（1）化合物的碱; 式（13）的化合物。