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公开(公告)号：US20160374963A1
公开(公告)日：2016-12-29
申请号：US15257255
申请日：2016-09-06
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/135 , B29C47/40 , B29C47/00 , A61K9/20 , B29C47/06
CPC分类号： A61K31/135 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K31/4725 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K36/67 , A61K36/81 , A61K45/06 , A61K47/10 , B29C48/0011 , B29C48/0022 , B29C48/022 , B29C48/03 , B29C48/18 , B29C48/40 , B29K2071/02 , B29K2105/0035 , B29K2105/0088 , B29K2105/25 , B29K2995/007 , B29K2995/0089 , B29L2031/753 , A61K2300/00
摘要： The invention relates to a dosage that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
摘要翻译： 本发明涉及热成型而不被挤出并且防止滥用的剂量，除了一种或多种可能遭受滥用的活性物质之外，还包含至少一种具有至少500N的断裂强度的合成或天然聚合物 和任选的生理上可接受的佐剂。 本发明还涉及用于生产所述剂型的相应方法。
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公开(公告)号：US20150359747A1
公开(公告)日：2015-12-17
申请号：US14834532
申请日：2015-08-25
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K31/135
CPC分类号： A61K31/135 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K31/4725 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K36/67 , A61K36/81 , A61K45/06 , A61K47/10 , B29C48/0011 , B29C48/0022 , B29C48/022 , B29C48/03 , B29C48/18 , B29C48/40 , B29K2071/02 , B29K2105/0035 , B29K2105/0088 , B29K2105/25 , B29K2995/007 , B29K2995/0089 , B29L2031/753 , A61K2300/00
摘要： The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
摘要翻译： 本发明涉及一种剂型，其不经挤出而被热成型并且被防止滥用，其包含至少一种具有至少500N的断裂强度的合成或天然聚合物，除了一种或多种可能经受 滥用和任选的生理上可接受的佐剂。 本发明还涉及用于生产所述剂型的相应方法。
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公开(公告)号：US20150056147A1
公开(公告)日：2015-02-26
申请号：US14527911
申请日：2014-10-30
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K47/38 , A61K31/485 , A61K31/5513 , A61K31/137
CPC分类号： A61K9/2054 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/205 , A61K9/4866 , A61K31/137 , A61K31/485 , A61K31/5513 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
摘要翻译： 一种固体给药形式，除了具有肠胃外滥用潜力的一种或多种活性物质外，还可防止肠胃外滥用并含有至少一种增粘剂。 基于从给药形式获得的提取物，当加入必要的最少量的含水液体时，该试剂形成当引入另一量的水性液体时保持视觉上不同的优选可注射的凝胶。
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公开(公告)号：US20170239185A1
公开(公告)日：2017-08-24
申请号：US15587501
申请日：2017-05-05
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K31/485 , A61K9/00
CPC分类号： A61K9/2054 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/205 , A61K9/4866 , A61K31/137 , A61K31/485 , A61K31/5513 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
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公开(公告)号：US20160361306A1
公开(公告)日：2016-12-15
申请号：US15245424
申请日：2016-08-24
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/485 , A61K9/48 , A61K31/137 , A61K9/00 , A61K9/20
CPC分类号： A61K9/2054 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/205 , A61K9/4866 , A61K31/137 , A61K31/485 , A61K31/5513 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
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公开(公告)号：US20160166517A1
公开(公告)日：2016-06-16
申请号：US15054201
申请日：2016-02-26
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/135 , A61K9/20
CPC分类号： A61K31/135 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K31/4725 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K36/67 , A61K36/81 , A61K45/06 , A61K47/10 , B29C48/0011 , B29C48/0022 , B29C48/022 , B29C48/03 , B29C48/18 , B29C48/40 , B29K2071/02 , B29K2105/0035 , B29K2105/0088 , B29K2105/25 , B29K2995/007 , B29K2995/0089 , B29L2031/753 , A61K2300/00
摘要： The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
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公开(公告)号：US20200375905A1
公开(公告)日：2020-12-03
申请号：US16994867
申请日：2020-08-17
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K9/48 , A61K31/137 , A61K31/5513 , A61K45/06 , A61K31/485 , A61K47/38 , A61K9/00
摘要： A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
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公开(公告)号：US20190282506A1
公开(公告)日：2019-09-19
申请号：US16434306
申请日：2019-06-07
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K31/485 , A61K9/00 , A61K45/06 , A61K31/5513 , A61K31/137 , A61K9/48 , A61K47/38
摘要： A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
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公开(公告)号：US20180318223A1
公开(公告)日：2018-11-08
申请号：US16032533
申请日：2018-07-11
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K47/38 , A61K45/06 , A61K31/5513 , A61K31/485 , A61K9/00 , A61K9/48 , A61K31/137
CPC分类号： A61K9/2054 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/205 , A61K9/4866 , A61K31/137 , A61K31/485 , A61K31/5513 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
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