公开(公告)号：US20220356202A1

公开(公告)日：2022-11-10

申请号：US17860468

申请日：2022-07-08

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Jian Ding ,  Zhenqing Zhang ,  Zhongping Xiao ,  Xiaoguang Du ,  Xianliang Xin

IPC分类号： C07H15/04 ,  A61P25/28 ,  A61K31/7032 ,  A61K31/715 ,  C08B37/00

摘要： The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m′ is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.

公开(公告)号：US11464794B2

公开(公告)日：2022-10-11

申请号：US17256853

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Zhenqing Zhang ,  Yingshen Jin ,  Zhongping Xiao ,  Jian Ding

IPC分类号： A61K31/702 ,  A61P25/28 ,  A61P29/00

摘要： The present invention relates to an alginic oligosaccharic diacid composition comprising a mannuronic diacid of Formula (IV) or a pharmaceutically acceptable salt thereof, wherein n is an integer selected from 1 to 9, m is selected from 0, 1 or 2, m′ is selected from 0 or 1, and wherein the total weight of alginic oligosaccharic diacid wherein n=1-5 accounts for more than 60% of the total weight of the composition; the total weight of guluronic acids accounts for less than 50% of the total weight of the composition.

公开(公告)号：US11406651B2

公开(公告)日：2022-08-09

申请号：US17256738

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/702 ,  A61P25/28

摘要： The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.

公开(公告)号：US11406653B2

公开(公告)日：2022-08-09

申请号：US17256950

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61P25/06 ,  A61K31/715 ,  A61K31/7032 ,  A61K31/702 ,  A61P25/04 ,  A61K31/7004 ,  A61K31/7016

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.

公开(公告)号：US11406659B2

公开(公告)日：2022-08-09

申请号：US17256854

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/734 ,  A61K31/7016 ,  A61K31/702 ,  A61P37/06 ,  A61K31/7012

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of inflammation.

公开(公告)号：US11406654B2

公开(公告)日：2022-08-09

申请号：US17256807

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/7032 ,  A61P25/16 ,  A61K31/715 ,  A61K31/716

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.

公开(公告)号：US11384111B2

公开(公告)日：2022-07-12

申请号：US16474928

申请日：2017-12-27

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Jian Ding ,  Zhenqing Zhang ,  Zhongping Xiao ,  Xiaoguang Du ,  Xianliang Xin

IPC分类号： A61P25/28 ,  A61K31/7032 ,  A61K31/715 ,  C08B37/00 ,  C07H15/04

摘要： The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m′ is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.

公开(公告)号：US11155569B2

公开(公告)日：2021-10-26

申请号：US16474350

申请日：2017-12-27

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD.

发明人： Zhongping Xiao ,  Zhenqing Zhang ,  Meiyu Geng ,  Jian Ding

IPC分类号： C07H1/08

摘要： The present invention relates to a method for degrading a polysaccharide in the field of food, medicine or chemical industry. In particular, a molecular chain of the polysaccharide is broken by ozone into polysaccharides with smaller molecular weights, oligoses and/or oligosaccharides. The polysaccharides include linear or branched glycans extracted from plants, traditional Chinese medicinal materials, animals, fungi, or microorganisms and sulfated polysaccharides or esterified polysaccharides formed by sulfation or esterification thereof. As an oxidizing agent in the reaction, the ozone can be used alone or can be used under the catalysis of a base, a metal ion, hydrogen peroxide, UV light, or activated carbon to accelerate the reaction. The method for degrading the polysaccharide in the present invention uses milder reaction conditions compared to a conventional acid-catalytic degradation method, has higher reaction efficiency and a controllable reaction process, does not need to use an acid, and reduces environmental pollution.