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公开(公告)号：US10006916B2
公开(公告)日：2018-06-26
申请号：US14005416
申请日：2012-03-15
CPC分类号： G01N33/58 , A61K38/00 , C07K7/08 , C07K14/001 , G01N33/6848 , G01N2458/15
摘要： Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (LC MS/MS). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag. The reagents and methods provided herein have general utility in analyte detection and encoding, for example, in biomolecular profiling, molecular diagnostics, and biochemical encoding.
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公开(公告)号：US20140303014A1
公开(公告)日：2014-10-09
申请号：US14005416
申请日：2012-03-15
CPC分类号： G01N33/58 , A61K38/00 , C07K7/08 , C07K14/001 , G01N33/6848 , G01N2458/15
摘要： Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (LC MS/MS). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag. The reagents and methods provided herein have general utility in analyte detection and encoding, for example, in biomolecular profiling, molecular diagnostics, and biochemical encoding.
摘要翻译： 本发明的一些方面提供了通过液相色谱串联质谱法（LC MS / MS）灵敏，定量和同时检测复杂生物样品中目标分析物的试剂和方法。 本发明的一些方面提供了用大量报道器编码的亲和试剂，用于敏感和定量地将感兴趣的分析物转化成质量标签。 本文提供的试剂和方法在分析物检测和编码中具有通用效用，例如在生物分子分析，分子诊断和生化编码中。
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公开(公告)号：US20110039717A1
公开(公告)日：2011-02-17
申请号：US12652000
申请日：2010-01-04
申请人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
发明人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
IPC分类号： C40B30/04
CPC分类号： G01N33/6845 , C12Q1/6834 , C12Q2563/131
摘要： Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.
摘要翻译： 本文提供了用于基于多核苷酸编码的蛋白质和底物多核苷酸的组合使用来检测和/或分选样品中靶标的方法和系统。 所述多核苷酸编码的蛋白质由特异性结合预定靶标的蛋白质和特异性结合底物多核苷酸的编码多核苷酸组成，其中所述底物多核苷酸附着于底物。
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公开(公告)号：US08354231B2
公开(公告)日：2013-01-15
申请号：US12652000
申请日：2010-01-04
申请人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
发明人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
CPC分类号： G01N33/6845 , C12Q1/6834 , C12Q2563/131
摘要： Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.
摘要翻译： 本文提供了用于基于多核苷酸编码的蛋白质和底物多核苷酸的组合使用来检测和/或分选样品中靶标的方法和系统。 所述多核苷酸编码的蛋白质由特异性结合预定靶标的蛋白质和特异性结合底物多核苷酸的编码多核苷酸组成，其中所述底物多核苷酸附着于底物。
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公开(公告)号：US20090017455A1
公开(公告)日：2009-01-15
申请号：US11888502
申请日：2007-08-01
申请人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
发明人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
IPC分类号： C12Q1/68
CPC分类号： G01N33/6845 , C12Q1/6834 , C12Q2563/131
摘要： Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded-protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.
摘要翻译： 本文提供了基于多核苷酸编码的蛋白质和底物多核苷酸的组合使用来检测和/或分选样品中靶标的方法和系统。 所述多核苷酸编码的蛋白质由特异性结合预定靶标的蛋白质和特异性结合底物多核苷酸的编码多核苷酸组成，其中所述底物多核苷酸附着于底物。
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6.发明授权Capture agents and related methods and systems for detecting and/or sorting targets 有权捕获代理以及用于检测和/或排序目标的相关方法和系统公开(公告)号：US08394590B2
公开(公告)日：2013-03-12
申请号：US12901151
申请日：2010-10-08
申请人： Gabriel A. Kwong , Caius G. Radu , Owen Witte , James R. Heath , Antoni Ribas
发明人： Gabriel A. Kwong , Caius G. Radu , Owen Witte , James R. Heath , Antoni Ribas
IPC分类号： C12Q1/68
CPC分类号： G01N33/505 , C12Q1/6834 , G01N33/54306 , C12Q2563/131
摘要： Polynucleotide-encoded capture agents for target detection and in particular modular polynucleotide-capture agents comprising a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion, and related compositions methods and systems.
摘要翻译： 用于靶检测的多核苷酸编码捕获剂，特别是模块化多核苷酸捕获剂，其包含靶结合组分，支架组分和通过可以受控制方式偶联和解耦的标准化分子单元形成的编码组分，以及相关组合物方法和 系统。
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7.发明申请CAPTURE AGENTS AND RELATED METHODS AND SYSTEMS FOR DETECTING AND/OR SORTING TARGETS 有权捕获试剂和相关的检测和/或分类目标的方法和系统公开(公告)号：US20110166034A1
公开(公告)日：2011-07-07
申请号：US12901151
申请日：2010-10-08
申请人： Gabriel A. Kwong , Caius G. Radu , Owen Witte , James R. Heath , Antoni Ribas
发明人： Gabriel A. Kwong , Caius G. Radu , Owen Witte , James R. Heath , Antoni Ribas
IPC分类号： C40B30/04
CPC分类号： G01N33/505 , C12Q1/6834 , G01N33/54306 , C12Q2563/131
摘要： Polynucleotide-encoded capture agents for target detection and in particular modular polynucleotide-capture agents comprising a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion, and related compositions methods and systems.
摘要翻译： 用于靶检测的多核苷酸编码捕获剂，特别是模块化多核苷酸捕获剂，其包含靶结合组分，支架组分和通过可以受控制方式偶联和解耦的标准化分子单元形成的编码组分，以及相关组合物方法和 系统。
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