公开(公告)号：US09209375B2

公开(公告)日：2015-12-08

申请号：US12175027

申请日：2008-07-17

Applicant: Akram Boukai ,  Yuri Bunimovich ,  William A. Goddard ,  James R. Heath ,  Jamil Tahir-Kheli

Inventor： Akram Boukai ,  Yuri Bunimovich ,  William A. Goddard ,  James R. Heath ,  Jamil Tahir-Kheli

IPC: H01L35/12 ,  H01L35/26 ,  H01L35/32 ,  H01L35/34

CPC classification number: H01L35/26 ,  H01L35/32 ,  H01L35/34 ,  H01L2924/0002 ,  H01L2924/00

Abstract: Methods and devices for controlling thermal conductivity and thermoelectric power of semiconductor nanowires are described. The thermal conductivity and the thermoelectric power are controlled substantially independently of the electrical conductivity of the nanowires by controlling dimensions and doping, respectively, of the nanowires. A thermoelectric device comprising p-doped and n-doped semiconductor nanowire thermocouples is also shown, together with a method to fabricate alternately p-doped and n-doped arrays of silicon nanowires.

Abstract translation: 描述了用于控制半导体纳米线的热导率和热电功率的方法和装置。 通过分别控制纳米线的尺寸和掺杂，热导率和热电功率基本上独立于纳米线的电导率来控制。 还示出了包括p掺杂和n掺杂半导体纳米线热电偶的热电器件，以及交替地制造硅纳米线的p掺杂和n掺杂阵列的方法。

公开(公告)号：US08906830B2

公开(公告)日：2014-12-09

申请号：US13035718

申请日：2011-02-25

Applicant: Heather Agnew ,  Rosemary Rohde ,  Steven Millward ,  Arundhati Nag ,  James R. Heath

Inventor： Heather Agnew ,  Rosemary Rohde ,  Steven Millward ,  Arundhati Nag ,  James R. Heath

IPC: C40B30/04 ,  G01N33/53 ,  G01N33/531 ,  G01N33/543 ,  C07D249/04

CPC classification number: G01N33/54306 ,  A61K38/02 ,  C07D249/04 ,  C07K1/00 ,  C12Q2523/109 ,  C40B30/04 ,  G01N33/531

Abstract: The present disclosure relates to capture agents for the detection and/or separation of one or more targets in a sample. Described herein are multi-ligand capture agents comprising two or more ligands, and related compositions, methods and systems. In certain embodiments, the capture agents disclosed herein can be used for performing assays, including but not limited to assays for the detection and/or separation of targets.

Abstract translation: 本公开涉及用于检测和/或分离样品中一种或多种靶的捕获剂。 本文描述的是包含两种或更多种配体以及相关组合物，方法和系统的多配体捕获剂。 在某些实施方案中，本文公开的捕获剂可用于进行测定，包括但不限于用于靶的检测和/或分离的测定。

公开(公告)号：US20090036324A1

公开(公告)日：2009-02-05

申请号：US12174601

申请日：2008-07-16

Applicant: Rong Fan ,  Habib Ahmad ,  James R. Heath

Inventor： Rong Fan ,  Habib Ahmad ,  James R. Heath

IPC: C40B30/04 ,  C40B40/00 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14 ,  C40B40/08 ,  C40B60/12

CPC classification number: G01N33/54393 ,  B01J19/0046 ,  B01J2219/00547 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0636 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N33/54366 ,  G01N33/582 ,  G01N2458/10

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

Abstract translation: 包含材料，特别是捕获剂和/或可检测目标的阵列和基底，沿着基本上平行的线连接到基底上，形成条形图案以及相关的方法和系统。

公开(公告)号：US07416911B2

公开(公告)日：2008-08-26

申请号：US10876276

申请日：2004-06-23

Applicant: James R. Heath ,  Yuri Bunimovich ,  Guanglu Ge ,  Kristen Beverly ,  John Nagarah ,  Michael Roukes ,  Peter Willis

Inventor： James R. Heath ,  Yuri Bunimovich ,  Guanglu Ge ,  Kristen Beverly ,  John Nagarah ,  Michael Roukes ,  Peter Willis

IPC: H01L21/306

CPC classification number: H01L51/0098 ,  B82Y10/00 ,  B82Y30/00 ,  H01L51/0595 ,  Y10S977/704 ,  Y10S977/762 ,  Y10S977/792 ,  Y10S977/794 ,  Y10S977/83 ,  Y10S977/899 ,  Y10S977/92 ,  Y10S977/924 ,  Y10S977/958

Abstract: A method by which silicon nanostructures may be selectively coated with molecules or biomolecules using an electrochemical process. This chemical process may be employed as a method for coating many different nanostructures within a circuit, each with a different molecular or biomolecular material. The density of devices within a circuit of devices that can be coated with different molecules is limited only by the ability to electronically address each device separately. This invention has applications toward the fabrication of molecular electronic circuitry and toward the fabrication of nanoelectronic molecular sensor arrays.

Abstract translation: 使用电化学方法可以用分子或生物分子选择性地涂布硅纳米结构的方法。 该化学方法可以用作在电路中涂覆许多不同纳米结构的方法，每种纳米结构具有不同的分子或生物分子材料。 可以用不同分子涂覆的器件的电路内的器件的密度仅受到分别对每个器件进行电子地址的能力的限制。 本发明具有制造分子电子电路和制造纳米电子分子传感器阵列的应用。

公开(公告)号：US6128214A

公开(公告)日：2000-10-03

申请号：US280189

申请日：1999-03-29

Applicant: Philip J. Kuekes ,  R. Stanley Williams ,  James R. Heath

Inventor： Philip J. Kuekes ,  R. Stanley Williams ,  James R. Heath

IPC: G11C11/14 ,  G11C11/36 ,  G11C13/02 ,  H01L27/28 ,  H01L51/00 ,  G11C11/00

CPC classification number: G11C13/025 ,  B82Y10/00 ,  G11C11/14 ,  G11C13/0009 ,  G11C2213/77 ,  G11C2213/81 ,  H01L27/28 ,  H01L51/0595 ,  Y10S977/943

Abstract: A molecular wire crossbar memory (MWCM) system is provided. The MWCM comprises a two-dimensional array of a plurality of nanometer-scale devices, each device comprising a junction formed by a pair of crossed wires where one wire crosses another and at least one connector species connecting the pair of crossed wires in the junction. The connector species comprises a bi-stable molecular switch. The junction forms either a resistor or a diode or an asymmetric non-linear resistor. The junction has a state that is capable of being altered by application of a first voltage and sensed by application of a second, non-destructive voltage.

Abstract translation: 提供分子线交叉存储器（MWCM）系统。 MWCM包括多个纳米级装置的二维阵列，每个装置包括由一对交叉导线形成的连接点，其中一根线交叉另一条线和连接该交叉线中的该对交叉线的至少一个连接器种类。 连接器种类包括双稳态分子开关。 该结形成电阻器或二极管或非对称非线性电阻器。 连接点具有能够通过施加第一电压并被施加第二非破坏性电压而被改变的状态。

公开(公告)号：US09863956B2

公开(公告)日：2018-01-09

申请号：US13386333

申请日：2009-07-22

Applicant: James R. Heath ,  Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Sylvia Tan ,  Shi Yun Yeo

Inventor： James R. Heath ,  Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Sylvia Tan ,  Shi Yun Yeo

IPC: G01N33/68 ,  C07K1/04 ,  C07K7/06 ,  C40B50/16 ,  C07K1/13

CPC classification number: G01N33/6848 ,  C07B2200/11 ,  C07K1/047 ,  C07K1/13 ,  C07K7/06 ,  C40B50/16 ,  G01N33/6812 ,  G01N33/6818

Abstract: Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.

公开(公告)号：US20140302998A1

公开(公告)日：2014-10-09

申请号：US13546575

申请日：2012-07-11

Applicant: James R. Heath ,  Arundhati Nag ,  Samir Das ,  Kaycie M. Deyle ,  Steven Wesley Millward ,  Paul Edward Kearney

Inventor： James R. Heath ,  Arundhati Nag ,  Samir Das ,  Kaycie M. Deyle ,  Steven Wesley Millward ,  Paul Edward Kearney

IPC: G01N33/574 ,  C12N15/10 ,  C12Q1/68

CPC classification number: C07K7/02 ,  A61K38/00 ,  A61K38/08 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/08 ,  C07K14/001 ,  C12N15/1058 ,  C12Q1/485 ,  C12Q1/6804 ,  G01N33/573 ,  G01N33/57449 ,  G01N33/5748 ,  G01N33/57496 ,  G01N2333/91205 ,  G01N2333/91215

Abstract: The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.

Abstract translation: 本申请提供稳定的基于肽的Akt捕获剂及其用作检测，诊断和治疗剂。 该应用进一步提供了使用迭代在珠粒原位点击化学开发稳定的基于肽的捕获剂（包括Akt捕获剂）的新方法。

公开(公告)号：US08394590B2

公开(公告)日：2013-03-12

申请号：US12901151

申请日：2010-10-08

Applicant: Gabriel A. Kwong ,  Caius G. Radu ,  Owen Witte ,  James R. Heath ,  Antoni Ribas

Inventor： Gabriel A. Kwong ,  Caius G. Radu ,  Owen Witte ,  James R. Heath ,  Antoni Ribas

IPC: C12Q1/68

CPC classification number: G01N33/505 ,  C12Q1/6834 ,  G01N33/54306 ,  C12Q2563/131

Abstract: Polynucleotide-encoded capture agents for target detection and in particular modular polynucleotide-capture agents comprising a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion, and related compositions methods and systems.

Abstract translation: 用于靶检测的多核苷酸编码捕获剂，特别是模块化多核苷酸捕获剂，其包含靶结合组分，支架组分和通过可以受控制方式偶联和解耦的标准化分子单元形成的编码组分，以及相关组合物方法和 系统。

公开(公告)号：US08206593B2

公开(公告)日：2012-06-26

申请号：US11792168

申请日：2005-12-05

Applicant: Chung-cheng Lee ,  Guodong Sui ,  Arkadij Elizarov ,  Hartmuth C. Kolb ,  Jiang Huang ,  James R. Heath ,  Michael E. Phelps ,  Stephen R. Quake ,  Hsian-rong Tseng ,  Paul Wyatt ,  Antoine Daridon

Inventor： Chung-cheng Lee ,  Guodong Sui ,  Arkadij Elizarov ,  Hartmuth C. Kolb ,  Jiang Huang ,  James R. Heath ,  Michael E. Phelps ,  Stephen R. Quake ,  Hsian-rong Tseng ,  Paul Wyatt ,  Antoine Daridon

IPC: B01D11/00 ,  B01J7/00 ,  B01D15/00

CPC classification number: B01J19/0093 ,  B01F11/0042 ,  B01F13/0059 ,  B01F2215/0404 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01L3/5027 ,  B33Y80/00 ,  C07B59/00

Abstract: New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

Abstract translation: 提供了用于进行化学反应的新型微流体装置。 该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。

公开(公告)号：US20120101268A1

公开(公告)日：2012-04-26

申请号：US13286418

申请日：2011-11-01

Applicant: Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

Inventor： Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

IPC: C07H21/00 ,  C08B37/00 ,  G21C1/00

CPC classification number: B01F11/0042 ,  B01F11/0071 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00916 ,  B01J2219/00927 ,  B01J2219/00986

Abstract: Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.

Abstract translation: 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。