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公开(公告)号：US20080242864A1
公开(公告)日：2008-10-02
申请号：US10593651
申请日：2005-03-02
申请人： Gabriele Fontana , Ezio Bombardelli , Cristian Samori , Eleonora Baldelli , Andrea Guerrini , Arturo Battaglia , Bruno Danieli
发明人： Gabriele Fontana , Ezio Bombardelli , Cristian Samori , Eleonora Baldelli , Andrea Guerrini , Arturo Battaglia , Bruno Danieli
IPC分类号： C07D459/00
CPC分类号： C07D459/00
摘要： The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).
摘要翻译： 本发明涉及从游离酸内酯（II）经由中间体11-O-去甲基存在酸内酯（III）合成脱苯西坦（Ia）的有效方法。
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公开(公告)号：US07468438B2
公开(公告)日：2008-12-23
申请号：US10593651
申请日：2005-03-02
申请人： Gabriele Fontana , Ezio Bombardelli , Cristian Samori , Eleonora Baldelli , Andrea Guerrini , Arturo Battaglia , Bruno Danieli
发明人： Gabriele Fontana , Ezio Bombardelli , Cristian Samori , Eleonora Baldelli , Andrea Guerrini , Arturo Battaglia , Bruno Danieli
IPC分类号： C07D459/00 , C07D491/22
CPC分类号： C07D459/00
摘要： The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).
摘要翻译： 本发明涉及从游离酸内酯（II）经由中间体11-O-去甲基存在酸内酯（III）合成脱苯西坦（Ia）的有效方法。
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3.发明授权Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate 有权制备14beta-羟基浆果赤霉素III-1,14-碳酸酯的方法公开(公告)号：US07317113B2
公开(公告)日：2008-01-08
申请号：US10492589
申请日：2002-07-15
IPC分类号： C07D301/27 , C07D307/77 , C07D407/00
CPC分类号： C07D493/08 , C07D305/14 , Y02P20/55
摘要： A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.
摘要翻译： 一种用于制备具有抗肿瘤活性的新型紫杉烷衍生物的14beta-羟基 - 浆果赤霉素III-1,14-碳酸酯的方法。
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4.发明申请公开(公告)号：US20060122258A1
公开(公告)日：2006-06-08
申请号：US10527164
申请日：2003-09-05
申请人： Gabriele Fontana , Ezio Bombardelli , Arturo Battaglia , Eleonora Baldelli , Andrea Guerrini , Maria Gelmi , Giacomo Carenzi , Donato Pocar
发明人： Gabriele Fontana , Ezio Bombardelli , Arturo Battaglia , Eleonora Baldelli , Andrea Guerrini , Maria Gelmi , Giacomo Carenzi , Donato Pocar
IPC分类号： A61K31/337 , C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described.
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5.发明授权Taxane derivatives functionalized at the 14-position and a process for the preparation thereof 失效在14位官能化的紫杉烷衍生物及其制备方法公开(公告)号：US07498452B2
公开(公告)日：2009-03-03
申请号：US10527164
申请日：2003-09-05
申请人： Gabriele Fontana , Ezio Bombardelli , Arturo Battaglia , Eleonora Baldelli , Andrea Guerrini , Maria Luisa Gelmi , Giacomo Carenzi , Donato Pocar
发明人： Gabriele Fontana , Ezio Bombardelli , Arturo Battaglia , Eleonora Baldelli , Andrea Guerrini , Maria Luisa Gelmi , Giacomo Carenzi , Donato Pocar
IPC分类号： C07D31/21
CPC分类号： C07D305/14 , Y02P20/55
摘要： A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described.
摘要翻译： 用于在式I的13-酮缩糊蛋白衍生物的14位官能化的通用方法，得到式II的衍生物，其中取代基如本公开所定义。 还描述了式II化合物在式III化合物中的转化，其中取代基如本公开所定义。
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公开(公告)号：US08193210B2
公开(公告)日：2012-06-05
申请号：US12373834
申请日：2007-07-16
申请人： Gabriele Fontana , Ezio Bombardelli , Carla Manzotti , Arturo Battaglia , Maria Grazia Allegri, legal representative , Cristian Samori
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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公开(公告)号：US20100010032A1
公开(公告)日：2010-01-14
申请号：US12373834
申请日：2007-06-16
IPC分类号： C07D491/22 , A61K31/4745 , A61P35/04
CPC分类号： C07D491/22
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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公开(公告)号：US08217053B2
公开(公告)日：2012-07-10
申请号：US12374963
申请日：2007-07-13
申请人： Gabriele Fontana , Ezio Bombardelli , Carla Manzotti , Arturo Battaglia , Maria Grazia Allegri, legal representative , Cristian Samori′
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
摘要翻译： 具有抗肿瘤活性的新型喜树碱衍生物，其制备方法，其作为抗肿瘤药物的用途和含有它们的药物组合物。
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公开(公告)号：US08076351B2
公开(公告)日：2011-12-13
申请号：US12374799
申请日：2007-07-12
申请人： Gabriele Fontana , Ezio Bombardelli , Carla Manzotti , Arturo Battaglia , Maria Grazia Allegri, legal representative , Cristian Samori
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： Y02P20/55
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
摘要翻译： 具有抗肿瘤活性的新型喜树碱衍生物，其制备方法，其作为抗肿瘤药物的用途和含有它们的药物组合物。
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公开(公告)号：US20100120816A1
公开(公告)日：2010-05-13
申请号：US12374963
申请日：2007-07-13
IPC分类号： A61K31/4375 , C07D491/147 , A61P35/00
CPC分类号： C07D491/22
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
摘要翻译： 具有抗肿瘤活性的新型喜树碱衍生物，其制备方法，其作为抗肿瘤药物的用途和含有它们的药物组合物。
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